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P66903

- THRC_MYCBO

UniProt

P66903 - THRC_MYCBO

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Protein
Threonine synthase
Gene
thrC, Mb1327
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Pyridoxal phosphate By similarity
Binding sitei326 – 3261Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Gene namesi
Name:thrC
Ordered Locus Names:Mb1327
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Threonine synthase
PRO_0000185638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi233413.Mb1327.

Structurei

3D structure databases

ProteinModelPortaliP66903.
SMRiP66903. Positions 10-358.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 2005Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
KOiK01733.
OMAiDPDWAVA.
OrthoDBiEOG6HMX9M.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P66903-1 [UniParc]FASTAAdd to Basket

« Hide

MTVPPTATHQ PWPGVIAAYR DRLPVGDDWT PVTLLEGGTP LIAATNLSKQ    50
TGCTIHLKVE GLNPTGSFKD RGMTMAVTDA LAHGQRAVLC ASTGNTSASA 100
AAYAARAGIT CAVLIPQGKI AMGKLAQAVM HGAKIIQIDG NFDDCLELAR 150
KMAADFPTIS LVNSVNPVRI EGQKTAAFEI VDVLGTAPDV HALPVGNAGN 200
ITAYWKGYTE YHQLGLIDKL PRMLGTQAAG AAPLVLGEPV SHPETIATAI 250
RIGSPASWTS AVEAQQQSKG RFLAASDEEI LAAYHLVARV EGVFVEPASA 300
ASIAGLLKAI DDGWVARGST VVCTVTGNGL KDPDTALKDM PSVSPVPVDP 350
VAVVEKLGLA 360
Length:360
Mass (Da):37,322
Last modified:October 11, 2004 - v1
Checksum:i43D27F553D5774B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42574.1.
RefSeqiNP_854981.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94188; CAD94188; Mb1327.
GeneIDi1090615.
KEGGimbo:Mb1327.
PATRICi18004603. VBIMycBov88188_1453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42574.1 .
RefSeqi NP_854981.1. NC_002945.3.

3D structure databases

ProteinModelPortali P66903.
SMRi P66903. Positions 10-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94188 ; CAD94188 ; Mb1327 .
GeneIDi 1090615.
KEGGi mbo:Mb1327.
PATRICi 18004603. VBIMycBov88188_1453.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000076503.
KOi K01733.
OMAi DPDWAVA.
OrthoDBi EOG6HMX9M.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF038945. Thr_synthase. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiTHRC_MYCBO
AccessioniPrimary (citable) accession number: P66903
Secondary accession number(s): Q10610, X2BHF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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