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Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatCUniRule annotation
Gene namesi
Name:tatCUniRule annotation
Ordered Locus Names:Mb2120c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei142 – 16221HelicalUniRule annotationAdd
BLAST
Transmembranei190 – 21021HelicalUniRule annotationAdd
BLAST
Transmembranei229 – 24921HelicalUniRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Sec-independent protein translocase protein TatCPRO_0000098091Add
BLAST

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP66896.
SMRiP66896. Positions 29-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000245380.
KOiK03118.
OMAiFPFVVDF.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P66896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAGLLKRL NPRNRRSRVN PDATMSLVDH LTELRTRLLI SLAAILVTTI
60 70 80 90 100
FGFVWYSHSI FGLDSLGEWL RHPYCALPQS ARADISADGE CRLLATAPFD
110 120 130 140 150
QFMLRLKVGM AAGIVLACPV WFYQLWAFIT PGLYQRERRF AVAFVIPAAV
160 170 180 190 200
LFVAGAVLAY LVLSKALGFL LTVGSDVQVT ALSGDRYFGF LLNLLVVFGV
210 220 230 240 250
SFEFPLLIVM LNLAGLLTYE RLKSWRRGLI FAMFVFAAIF TPGSDPFSMT
260 270 280 290 300
ALGAALTVLL ELAIQIARVH DKRKAKREAA IPDDEASVID PPSPVPAPSV

IGSHDDVT
Length:308
Mass (Da):33,855
Last modified:October 11, 2004 - v1
Checksum:i9FC9B8DC674ECCCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43373.1.
RefSeqiNP_855769.1. NC_002945.3.
WP_003410764.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43373; CDO43373; Mb2120c.
GeneIDi1091141.
KEGGimbo:Mb2120c.
PATRICi18006368. VBIMycBov88188_2331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43373.1.
RefSeqiNP_855769.1. NC_002945.3.
WP_003410764.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP66896.
SMRiP66896. Positions 29-269.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43373; CDO43373; Mb2120c.
GeneIDi1091141.
KEGGimbo:Mb2120c.
PATRICi18006368. VBIMycBov88188_2331.

Phylogenomic databases

HOGENOMiHOG000245380.
KOiK03118.
OMAiFPFVVDF.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTATC_MYCBO
AccessioniPrimary (citable) accession number: P66896
Secondary accession number(s): Q10702, X2BK44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.