P66887 (TATA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sec-independent protein translocase protein TatA

Gene names

Name:	tatA
Ordered Locus Names:	BMEI1084

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system By similarity. HAMAP-Rule MF_00236
Subunit structure	The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon By similarity.
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity HAMAP-Rule MF_00236.
Sequence similarities	Belongs to the TatA/E family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein secretion Inferred from electronic annotation. Source: InterPro protein transport by the Tat complex Inferred from electronic annotation. Source: HAMAP
Cellular_component	TAT protein transport complex Inferred from electronic annotation. Source: HAMAP integral to plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular_function	protein transmembrane transporter activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 72	72	Sec-independent protein translocase protein TatA HAMAP-Rule MF_00236		PRO_0000097930
Regions
	Transmembrane	1 – 21	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P66887 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5F57A505041227AB	FASTA	72	7,999
	10 20 30 40 50 60 MGSFSIWHWL IVLAVVLLLF GRGKIPELMG DVAKGIKNFK QGMADEDAKE DPRTIDAKAE 70 EPVKDVKKTT KS

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52265.1.
PIR	AF3387.
RefSeq	NP_540001.1. NC_003317.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI1084.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL52265; AAL52265; BMEI1084.
GeneID	1196795.
KEGG	bme:BMEI1084.
PATRIC	17797862. VBIBruMel146950_0747.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000245363.
KO	K03116.
OMA	SIWHWMI.
ProtClustDB	PRK00720.
Family and domain databases
HAMAP	MF_00236. TatA_E.
InterPro	IPR003369. TatA/B/E. IPR006312. TatA_E. [Graphical view]
Pfam	PF02416. MttA_Hcf106. 1 hit. [Graphical view]
TIGRFAMs	TIGR01411. tatAE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TATA_BRUME

Accession

Primary (citable) accession number: P66887
Secondary accession number(s): Q8G142, Q8YGS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program