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P66882

- SURE_SALTI

UniProt

P66882 - SURE_SALTI

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Protein
5'/3'-nucleotidase SurE
Gene
surE, STY3052, t2828
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs By similarity.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Divalent metal cation By similarity
Metal bindingi9 – 91Divalent metal cation By similarity
Metal bindingi39 – 391Divalent metal cation By similarity
Metal bindingi92 – 921Divalent metal cation By similarity

GO - Molecular functioni

  1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
  2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
  3. exopolyphosphatase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-HAMAP
  5. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurE (EC:3.1.3.5, EC:3.1.3.6)
    Alternative name(s):
    Exopolyphosphatase (EC:3.6.1.11)
    Nucleoside monophosphate phosphohydrolase
    Gene namesi
    Name:surE
    Ordered Locus Names:STY3052, t2828
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    Cytoplasm Reviewed prediction UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532535'/3'-nucleotidase SurEUniRule annotation
    PRO_0000111840Add
    BLAST

    Proteomic databases

    PRIDEiP66882.

    Interactioni

    Protein-protein interaction databases

    STRINGi220341.STY3052.

    Structurei

    3D structure databases

    ProteinModelPortaliP66882.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.

    Phylogenomic databases

    HOGENOMiHOG000122500.
    KOiK03787.
    OMAiVCDLIPK.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P66882-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILLSNDDG VHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS    50
    LRTFTFDNGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD 100
    VIYSGTVAAA MEGRHLGFPA LAVSLNGYQH YDTAAAVTCA LLRGLSREPL 150
    RTGRILNVNV PDLPLAQVKG IRVTRCGSRH PADKVIPQED PRGNTLYWIG 200
    PPGDKYDAGP DTDFAAVDEG YVSVTPLHVD LTAHSAHDVV SDWLDSVGVG 250
    TQW 253
    Length:253
    Mass (Da):26,980
    Last modified:October 11, 2004 - v1
    Checksum:iA8C4DD6EE42372F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD06033.1.
    AE014613 Genomic DNA. Translation: AAO70385.1.
    RefSeqiNP_457316.1. NC_003198.1.
    NP_806525.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO70385; AAO70385; t2828.
    CAD06033; CAD06033; CAD06033.
    GeneIDi1249355.
    KEGGisty:STY3052.
    PATRICi18544151. VBISalEnt120419_3105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD06033.1 .
    AE014613 Genomic DNA. Translation: AAO70385.1 .
    RefSeqi NP_457316.1. NC_003198.1.
    NP_806525.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali P66882.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 220341.STY3052.

    Proteomic databases

    PRIDEi P66882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO70385 ; AAO70385 ; t2828 .
    CAD06033 ; CAD06033 ; CAD06033 .
    GeneIDi 1249355.
    KEGGi sty:STY3052.
    PATRICi 18544151. VBISalEnt120419_3105.

    Phylogenomic databases

    HOGENOMi HOG000122500.
    KOi K03787.
    OMAi VCDLIPK.
    OrthoDBi EOG68WR45.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiSURE_SALTI
    AccessioniPrimary (citable) accession number: P66882
    Secondary accession number(s): Q8XFG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: May 14, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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