Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi92Divalent metal cationUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:STM2927
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001118391 – 2535'/3'-nucleotidase SurEAdd BLAST253

Proteomic databases

PaxDbiP66881.
PRIDEiP66881.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2927.

Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi14 – 24Combined sources11
Beta strandi27 – 36Combined sources10
Beta strandi53 – 55Combined sources3
Beta strandi61 – 63Combined sources3
Helixi68 – 77Combined sources10
Beta strandi80 – 82Combined sources3
Beta strandi85 – 94Combined sources10
Helixi98 – 103Combined sources6
Helixi105 – 111Combined sources7
Turni112 – 115Combined sources4
Beta strandi116 – 118Combined sources3
Beta strandi120 – 129Combined sources10
Helixi131 – 147Combined sources17
Beta strandi154 – 160Combined sources7
Helixi165 – 167Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi178 – 180Combined sources3
Beta strandi185 – 189Combined sources5
Beta strandi195 – 199Combined sources5
Beta strandi205 – 207Combined sources3
Helixi213 – 218Combined sources6
Beta strandi222 – 227Combined sources6
Helixi234 – 236Combined sources3
Helixi237 – 247Combined sources11
Beta strandi249 – 251Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V4NX-ray1.70A1-253[»]
2V4OX-ray2.71A/B/C/D1-253[»]
4G9OX-ray2.12A/B1-253[»]
4GADX-ray2.35A/B1-253[»]
4RYTX-ray2.09A1-253[»]
4RYUX-ray2.04A/B/C/D1-253[»]
4XEPX-ray1.50A1-253[»]
4XERX-ray1.97A/B/C/D1-253[»]
4XGBX-ray2.23A/B/C/D1-253[»]
4XGPX-ray1.90A/B/C/D1-253[»]
4XH8X-ray3.56A/B1-253[»]
4XJ7X-ray1.60A/B/C/D1-253[»]
ProteinModelPortaliP66881.
SMRiP66881.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP66881.

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122500.
KOiK03787.
OMAiANGFYYV.
PhylomeDBiP66881.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

P66881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLSNDDG VHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS
60 70 80 90 100
LRTFTFDNGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD
110 120 130 140 150
VIYSGTVAAA MEGRHLGFPA LAVSLNGYQH YDTAAAVTCA LLRGLSREPL
160 170 180 190 200
RTGRILNVNV PDLPLAQVKG IRVTRCGSRH PADKVIPQED PRGNTLYWIG
210 220 230 240 250
PPGDKYDAGP DTDFAAVDEG YVSVTPLHVD LTAHSAHDVV SDWLDSVGVG

TQW
Length:253
Mass (Da):26,980
Last modified:October 11, 2004 - v1
Checksum:iA8C4DD6EE42372F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21807.1.
RefSeqiNP_461848.1. NC_003197.1.
WP_001221538.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21807; AAL21807; STM2927.
GeneIDi1254450.
KEGGistm:STM2927.
PATRICi32384539. VBISalEnt20916_3081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21807.1.
RefSeqiNP_461848.1. NC_003197.1.
WP_001221538.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V4NX-ray1.70A1-253[»]
2V4OX-ray2.71A/B/C/D1-253[»]
4G9OX-ray2.12A/B1-253[»]
4GADX-ray2.35A/B1-253[»]
4RYTX-ray2.09A1-253[»]
4RYUX-ray2.04A/B/C/D1-253[»]
4XEPX-ray1.50A1-253[»]
4XERX-ray1.97A/B/C/D1-253[»]
4XGBX-ray2.23A/B/C/D1-253[»]
4XGPX-ray1.90A/B/C/D1-253[»]
4XH8X-ray3.56A/B1-253[»]
4XJ7X-ray1.60A/B/C/D1-253[»]
ProteinModelPortaliP66881.
SMRiP66881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2927.

Proteomic databases

PaxDbiP66881.
PRIDEiP66881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21807; AAL21807; STM2927.
GeneIDi1254450.
KEGGistm:STM2927.
PATRICi32384539. VBISalEnt20916_3081.

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122500.
KOiK03787.
OMAiANGFYYV.
PhylomeDBiP66881.

Miscellaneous databases

EvolutionaryTraceiP66881.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSURE_SALTY
AccessioniPrimary (citable) accession number: P66881
Secondary accession number(s): Q8XFG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.