P66827 (SODC_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:	sodC
Ordered Locus Names:	BRA0703, BS1330_II0696

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.
Sequence caution	The sequence AAN33888.1 differs from that shown. Reason: Erroneous initiation. The sequence AEM20163.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 174	154	Superoxide dismutase [Cu-Zn]		PRO_0000032822
Sites
	Metal binding	68	1	Copper; catalytic By similarity
	Metal binding	70	1	Copper; catalytic By similarity
	Metal binding	93	1	Copper; catalytic By similarity
	Metal binding	93	1	Zinc; structural By similarity
	Metal binding	102	1	Zinc; structural By similarity
	Metal binding	110	1	Zinc; structural By similarity
	Metal binding	113	1	Zinc; structural By similarity
	Metal binding	148	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	75 ↔ 170		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P66827 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 08B355A9A6F7F67A	FASTA	174	18,262
	10 20 30 40 50 60 MMKSLFIAST MVLMAFPAFA ESTTVKMYEA LPTGPGKEVG TVVISEAPGG LHFKVNMEKL 70 80 90 100 110 120 TPGYHGFHVH ENPSCAPGEK DGKIVPALAA GGHYDPGNTH HHLGPEGDGH MGDLPRLSAN 130 140 150 160 170 ADGKVSETVV APHLKKLAEI KQRSLMVHVG GDNYSDKPEP LGGGGARFAC GVIE

References

[1]	"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[2]	"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed: 22038969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014292 Genomic DNA. Translation: AAN33888.1. Different initiation. CP002998 Genomic DNA. Translation: AEM20163.1. Different initiation.
RefSeq	NP_699883.1. NC_004311.2.
3D structure databases
ProteinModelPortal	P66827.
SMR	P66827. Positions 21-174.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1165145.
GenomeReviews	Gene locus BRA0703 in contig AE014292_GR.
KEGG	bms:BRA0703.
PATRIC	17794214. VBIBruSui107850_2918.
TIGR	BRA0703.
Phylogenomic databases
HOGENOM	HBG609879.
PhylomeDB	P66827.
ProtClustDB	CLSK898879.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_A0703-MONOMER.
Family and domain databases
InterPro	IPR024136. SOD_Cu/Zn. IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
KO	K04565.
PANTHER	PTHR10003:SF11. PTHR10003:SF11. 1 hit. PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_BRUSU

Accession

Primary (citable) accession number: P66827
Secondary accession number(s): G0KD75, P58645

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program