Reviewed, UniProtKB/Swiss-Prot P66826 (SODC_BRUME)

Names and origin

Protein names

Recommended name:
    Superoxide dismutase [Cu-Zn]
    EC=1.15.1.1

Gene names

Name:	sodC
Ordered Locus Names:	BMEII0581

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 174	154	Superoxide dismutase [Cu-Zn]		PRO_0000032821
Sites
	Metal binding	68	1	Copper; catalytic By similarity
	Metal binding	70	1	Copper; catalytic By similarity
	Metal binding	93	1	Copper; catalytic By similarity
	Metal binding	93	1	Zinc; structural By similarity
	Metal binding	102	1	Zinc; structural By similarity
	Metal binding	110	1	Zinc; structural By similarity
	Metal binding	113	1	Zinc; structural By similarity
	Metal binding	148	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	75 ↔ 170		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P66826-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 08B355A9A6F7F67A	FASTA	174	18,262
	10 20 30 40 50 60 MMKSLFIAST MVLMAFPAFA ESTTVKMYEA LPTGPGKEVG TVVISEAPGG LHFKVNMEKL 70 80 90 100 110 120 TPGYHGFHVH ENPSCAPGEK DGKIVPALAA GGHYDPGNTH HHLGPEGDGH MGDLPRLSAN 130 140 150 160 170 ADGKVSETVV APHLKKLAEI KQRSLMVHVG GDNYSDKPEP LGGGGARFAC GVIE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008918 Genomic DNA. Translation: AAL53823.1.
PIR	AD3582.
RefSeq	NP_541559.1.
3D structure databases
HSSP	HSSP built from PDB template 1EQW based on UniProtKB P53636.
SMR	P66826. Positions 21-174.
ModBase	Search...
Genome annotation databases
GeneID	1198353.
GenomeReviews	Gene locus BMEII0581 in contig AE008918_GR.
KEGG	bme:BMEII0581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P66826.
OMA	EIKGHAL.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEII0581-MON.
BRENDA	1.15.1.1. 277959.
Family and domain databases
InterPro	IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
ProDom	PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_BRUME

Accession

Primary (citable) accession number: P66826
Secondary accession number(s): P58645

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)