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P66799 (EMBR_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable regulatory protein embR
Gene names
Name:embR
Ordered Locus Names:Rv1267c, MT1305
ORF Names:MTCY50.15
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Post-translational modification

Phosphorylated on threonine residue(s) by pknH. Ref.3

Sequence similarities

Belongs to the AfsR/DnrI/RedD regulatory family.

Contains 1 FHA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Probable regulatory protein embR
PRO_0000110008

Regions

Domain308 – 35750FHA

Experimental info

Mutagenesis3121R → A: Abolished phosphorylation. Ref.3
Mutagenesis3261S → A: Abolished phosphorylation. Ref.3
Mutagenesis3481N → A: Abolished phosphorylation. Ref.3

Secondary structure

1 .............................................................. 388
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P66799 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8221B6EAF1C33354

FASTA38841,933
        10         20         30         40         50         60 
MAGSATVEKR LDFGLLGPLQ MTIDGTPVPS GTPKQRAVLA MLVINRNRPV GVDALITALW 

        70         80         90        100        110        120 
EEWPPSGARA SIHSYVSNLR KLLGGAGIDP RVVLAAAPPG YRLSIPDNTC DLGRFVAEKT 

       130        140        150        160        170        180 
AGVHAAAAGR FEQASRHLSA ALREWRGPVL DDLRDFQFVE PFATALVEDK VLAHTAKAEA 

       190        200        210        220        230        240 
EIACGRASAV IAELEALTFE HPYREPLWTQ LITAYYLSDR QSDALGAYRR VKTTLADDLG 

       250        260        270        280        290        300 
IDPGPTLRAL NERILRQQPL DAKKSAKTTA AGTVTVLDQR TMASGQQAVA YLHDIASGRG 

       310        320        330        340        350        360 
YPLQAAATRI GRLHDNDIVL DSANVSRHHA VIVDTGTNYV INDLRSSNGV HVQHERIRSA 

       370        380 
VTLNDGDHIR ICDHEFTFQI SAGTHGGT

« Hide

References

« Hide 'large scale' references
[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[3]"An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis."
Molle V., Kremer L., Girard-Blanc C., Besra G.S., Cozzone A.J., Prost J.F.
Biochemistry 42:15300-15309(2003) [PubMed: 14690440] [Abstract]
Cited for: PHOSPHORYLATION, MUTAGENESIS OF ARG-312; SER-326 AND ASN-348.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842576 Genomic DNA. Translation: CAB00888.1.
AE000516 Genomic DNA. Translation: AAK45564.1.
PIRC70754.
RefSeqNP_215783.1. NC_000962.2.
NP_335750.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FEZX-ray2.00A1-388[»]
2FF4X-ray1.90A/B1-388[»]
ProteinModelPortalP66799.
SMRP66799. Positions 8-386.
ModBaseSearch...

PTM databases

PhosSiteP66799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002816; EBMYCP00000002816; EBMYCG00000002814.
EBMYCT00000070774; EBMYCP00000068833; EBMYCG00000070769.
GeneID887026.
924767.
GenomeReviewsGene locus MT1305 in contig AE000516_GR.
Gene locus Rv1267c in contig AL123456_GR.
KEGGmtc:MT1305.
mtu:Rv1267c.
PATRIC18124634. VBIMycTub22151_1436.
TIGRMT1305.

Organism-specific databases

TubercuListRv1267c.

Phylogenomic databases

GeneTreeEBGT00050000014812.
HOGENOMHBG700221.
OMALLGPLEM.
ProtClustDBCLSK791063.

Family and domain databases

InterProIPR005158. BTAD.
IPR000253. FHA_dom.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR008984. SMAD_FHA_domain.
IPR011990. TPR-like_helical.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:2.60.200.20. FHA. 1 hit.
G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF03704. BTAD. 1 hit.
PF00498. FHA. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM01043. BTAD. 1 hit.
SM00240. FHA. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF46894. Bipartite_resp_reg_C-effector. 1 hit.
SSF49879. SMAD_FHA. 1 hit.
PROSITEPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEMBR_MYCTU
AccessionPrimary (citable) accession number: P66799
Secondary accession number(s): Q11052
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents