Skip Header

Contribute Send feedback
Read comments (?) or add your own

P66775 (BUTA_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diacetyl reductase [(S)-acetoin forming]
EC=1.1.1.304
Alternative name(s):
Acetoin(diacetyl) reductase
Short name=AR
Meso-2,3-butanediol dehydrogenase
Gene names
Name:butA
Ordered Locus Names:SAV0126
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH By similarity.

Catalytic activity

(S)-acetoin + NAD+ = diacetyl + NADH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processacetoin catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functiondiacetyl reductase ((S)-acetoin forming) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Diacetyl reductase [(S)-acetoin forming]
PRO_0000054540

Regions

Nucleotide binding8 – 3225NAD By similarity

Sites

Active site1541Proton acceptor By similarity
Active site1581 By similarity
Binding site1411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P66775 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 114AFD0DC5D780CF

FASTA25827,216
        10         20         30         40         50         60 
MTNNKVALVT GGAQGIGFKI AERLVEDGFK VAVVDFNEEG AKAAALKLSS DGTKAIAIKA 

        70         80         90        100        110        120 
DVSNRDDVFN AVRQTAAQFG DFHVMVNNAG LGPTTPIDTI TEEQFKTVYG VNVAGVLWGI 

       130        140        150        160        170        180 
QAAHEQFKKF NHGGKIINAT SQAGVEGNPG LSLYCSTKFA VRGLTQVAAQ DLASEGITVN 

       190        200        210        220        230        240 
AFAPGIVQTP MMESIAVATA EEAGKPEAWG WEQFTSQIAL GRVSQPEDVS NVVSFLAGKD 

       250 
SDYITGQTII VDGGMRFR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB56288.1.
RefSeqNP_370650.1. NC_002758.2.

3D structure databases

ProteinModelPortalP66775.
SMRP66775. Positions 4-257.
ModBaseSearch...

Protein-protein interaction databases

STRINGP66775.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000006679; EBSTAP00000006497; EBSTAG00000006678.
GeneID1120085.
GenomeReviewsGene locus SAV0126 in contig BA000017_GR.
KEGGsav:SAV0126.
PATRIC19560853. VBIStaAur52173_0124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
GeneTreeEBGT00050000023864.
HOGENOMHBG750976.
OMAVAACVAY.
ProtClustDBPRK08643.

Enzyme and pathway databases

BioCycSAUR158878:SAV0126-MONOMER.

Family and domain databases

InterProIPR014007. 23BDH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK03366.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR02415. 23BDH. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUTA_STAAM
AccessionPrimary (citable) accession number: P66775
Secondary accession number(s): Q99X89
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents