P66774 (SDHL_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-serine dehydratase
Short name=SDH
EC=4.3.1.17

Alternative name(s):
L-serine deaminase
Short name=L-SD

Gene names

Name:	sdaA
Ordered Locus Names:	Mb0070c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster Probable.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	L-serine dehydratase		PRO_0000171910

Sequences

	Sequence		Length	Mass (Da)
	P66774 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 228C62DCE67FEAFD	FASTA	461	48,576
	10 20 30 40 50 60 MTISVFDLFT IGIGPSSSHT VGPMRAANQF VVALRRRGHL DDLEAMRVDL FGSLAATGAG 70 80 90 100 110 120 HGTMSAILLG LEGCQPETIT TEHKERRLAE IAASGVTRIG GVIPVPLTER DIDLHPDIVL 130 140 150 160 170 180 PTHPNGMTFT AAGPHGRVLA TETYFSVGGG FIVTEQTSGN SGQHPCSVAL PYVSAQELLD 190 200 210 220 230 240 ICDRLDVSIS EAALRNETCC RTENEVRAAL LHLRDVMVEC EQRSIAREGL LPGGLRVRRR 250 260 270 280 290 300 AKVWYDRLNA EDPTRKPEFA EDWVNLVALA VNEENASGGR VVTAPTNGAA GIVPAVLHYA 310 320 330 340 350 360 IHYTSAGAGD PDDVTVRFLL TAGAIGSLFK ERASISGAEV GCQGEVGSAA AMAAAGLAEI 370 380 390 400 410 420 LGGTPRQVEN AAEIAMEHSL GLTCDPIAGL VQIPCIERNA ISAGKAINAA RMALRGDGIH 430 440 450 460 RVTLDQVIDT MRATGADMHT KYKETSAGGL AINVAVNIVE C

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248334 Genomic DNA. Translation: CAD92932.1.
RefSeq	NP_853739.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P66774.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000016408; EBMYCP00000016243; EBMYCG00000016403.
GeneID	1093594.
GenomeReviews	Gene locus Mb0070c in contig BX248333_GR.
KEGG	mbo:Mb0070c.
PATRIC	18001822. VBIMycBov88188_0079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000018290.
HOGENOM	HBG304565.
OMA	WAAMREC.
ProtClustDB	CLSK790234.
Enzyme and pathway databases
BioCyc	MBOV233413:MB0070C-MONOMER.
Family and domain databases
InterPro	IPR004644. Fe-S_L-Ser_mono. IPR005130. Ser_deHydtase-like_asu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
KO	K01752.
Pfam	PF03313. SDH_alpha. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00720. Sda_mono. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHL_MYCBO

Accession

Primary (citable) accession number: P66774
Secondary accession number(s): O53614

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program