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P66742 (RUVA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holliday junction ATP-dependent DNA helicase RuvA

EC=3.6.4.12
Gene names
Name:ruvA
Ordered Locus Names:BMEI0333
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity. HAMAP-Rule MF_00031

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_00031

Subunit structure

Forms a complex with RuvB By similarity. HAMAP-Rule MF_00031

Sequence similarities

Belongs to the RuvA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Holliday junction ATP-dependent DNA helicase RuvA HAMAP-Rule MF_00031
PRO_0000094610

Sequences

Sequence LengthMass (Da)Tools
P66742 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6BC6165956AAAF25

FASTA20521,227
        10         20         30         40         50         60 
MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE TYVREDMIRL 

        70         80         90        100        110        120 
YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN AIALRDIAMV SRAPGVGKKV 

       130        140        150        160        170        180 
AERIVTELKN KAPAFAGEAS GTIGLKQELG AGAAPAPVAD AVSALSNLGY SRDQAANAVA 

       190        200 
AALKETGEGA DSAKLIRLGL KELSQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL51514.1.
PIRAG3293.
RefSeqNP_539250.1. NC_003317.1.

3D structure databases

ProteinModelPortalP66742.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0333.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL51514; AAL51514; BMEI0333.
GeneID1196044.
KEGGbme:BMEI0333.
PATRIC17802317. VBIBruMel146950_3475.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000057115.
KOK03550.
OMAVGYQVHC.
OrthoDBEOG679THG.
ProtClustDBPRK00116.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00031. DNA_helic_RuvA.
InterProIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00084. ruvA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVA_BRUME
AccessionPrimary (citable) accession number: P66742
Secondary accession number(s): Q8YIV6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names