Reviewed,
UniProtKB/Swiss-Prot P66742 (RUVA_BRUME)
Last modified
November 24, 2009.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Holliday junction ATP-dependent DNA helicase ruvA EC=3.6.1.- | ||||
| Gene names |
| ||||
| Organism | Brucella melitensis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29459 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 205 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB By similarity. |
| Subunit structure | Forms a complex with ruvB. HAMAP MF_00031 |
| Sequence similarities | Belongs to the ruvA family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA recombination DNA repair SOS response |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Helicase Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repairInferred from electronic annotation. Source: HAMAP SOS responseInferred from electronic annotation. Source: HAMAP |
| Cellular component | Holliday junction helicase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA bindingInferred from electronic annotation. Source: UniProtKB-KW four-way junction helicase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 205 | 205 | Holliday junction ATP-dependent DNA helicase ruvA HAMAP MF_00031 | PRO_0000094610 | |||
Sequences
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References
| [1] | "The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. Overbeek R.Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1. |
Cross-references
Sequence databases | |
|---|---|
| AE008917 Genomic DNA. Translation: AAL51514.1. | |
| PIR | AG3293. |
| RefSeq | NP_539250.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1196044. |
| GenomeReviews | Gene locus BMEI0333 in contig AE008917_GR. |
| KEGG | bme:BMEI0333. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P66742. |
| OMA | DCHGVGY |
Enzyme and pathway databases | |
| BioCyc | BMEL224914:BMEI0333-MON. |
Family and domain databases | |
| HAMAP | MF_00031. [Tree] |
| InterPro | IPR011114. DNA_helicas_Holl-junc_RuvA_C. IPR013849. DNA_helicase_Holl-junc_RuvA_I. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR000085. RuvA. IPR010994. RuvA_2-like. [Graphical view] |
| Gene3D | G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit. |
| Pfam | PF07499. RuvA_C. 1 hit. PF01330. RuvA_N. 1 hit. [Graphical view] |
| SMART | SM00278. HhH1. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR00084. ruvA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | RUVA_BRUME | ||||||||
| Accession | Primary (citable) accession number: P66742 Secondary accession number(s): Q8YIV6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella melitensis Brucella melitensis (strain 16M): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


