Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P66742

- RUVA_BRUME

UniProt

P66742 - RUVA_BRUME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. four-way junction helicase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. SOS response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:BMEI0333
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. Holliday junction helicase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Holliday junction ATP-dependent DNA helicase RuvAPRO_0000094610Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0333.

Structurei

3D structure databases

ProteinModelPortaliP66742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000057115.
KOiK03550.
OMAiRNEVFLA.
OrthoDBiEOG679THG.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

P66742-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE
60 70 80 90 100
TYVREDMIRL YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN
110 120 130 140 150
AIALRDIAMV SRAPGVGKKV AERIVTELKN KAPAFAGEAS GTIGLKQELG
160 170 180 190 200
AGAAPAPVAD AVSALSNLGY SRDQAANAVA AALKETGEGA DSAKLIRLGL

KELSQ
Length:205
Mass (Da):21,227
Last modified:October 11, 2004 - v1
Checksum:i6BC6165956AAAF25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51514.1.
PIRiAG3293.
RefSeqiNP_539250.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51514; AAL51514; BMEI0333.
GeneIDi1196044.
KEGGibme:BMEI0333.
PATRICi17802317. VBIBruMel146950_3475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51514.1 .
PIRi AG3293.
RefSeqi NP_539250.1. NC_003317.1.

3D structure databases

ProteinModelPortali P66742.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL51514 ; AAL51514 ; BMEI0333 .
GeneIDi 1196044.
KEGGi bme:BMEI0333.
PATRICi 17802317. VBIBruMel146950_3475.

Phylogenomic databases

HOGENOMi HOG000057115.
KOi K03550.
OMAi RNEVFLA.
OrthoDBi EOG679THG.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00031. DNA_helic_RuvA.
InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view ]
Pfami PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view ]
SMARTi SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00084. ruvA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiRUVA_BRUME
AccessioniPrimary (citable) accession number: P66742
Secondary accession number(s): Q8YIV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3