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P66742

- RUVA_BRUME

UniProt

P66742 - RUVA_BRUME

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Protein
Holliday junction ATP-dependent DNA helicase RuvA
Gene
ruvA, BMEI0333
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. four-way junction helicase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. SOS response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvA (EC:3.6.4.12)
Gene namesi
Name:ruvA
Ordered Locus Names:BMEI0333
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. Holliday junction helicase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation
PRO_0000094610Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0333.

Structurei

3D structure databases

ProteinModelPortaliP66742.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.

Phylogenomic databases

HOGENOMiHOG000057115.
KOiK03550.
OMAiRNEVFLA.
OrthoDBiEOG679THG.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

P66742-1 [UniParc]FASTAAdd to Basket

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MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE    50
TYVREDMIRL YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN 100
AIALRDIAMV SRAPGVGKKV AERIVTELKN KAPAFAGEAS GTIGLKQELG 150
AGAAPAPVAD AVSALSNLGY SRDQAANAVA AALKETGEGA DSAKLIRLGL 200
KELSQ 205
Length:205
Mass (Da):21,227
Last modified:October 11, 2004 - v1
Checksum:i6BC6165956AAAF25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51514.1.
PIRiAG3293.
RefSeqiNP_539250.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51514; AAL51514; BMEI0333.
GeneIDi1196044.
KEGGibme:BMEI0333.
PATRICi17802317. VBIBruMel146950_3475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51514.1 .
PIRi AG3293.
RefSeqi NP_539250.1. NC_003317.1.

3D structure databases

ProteinModelPortali P66742.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL51514 ; AAL51514 ; BMEI0333 .
GeneIDi 1196044.
KEGGi bme:BMEI0333.
PATRICi 17802317. VBIBruMel146950_3475.

Phylogenomic databases

HOGENOMi HOG000057115.
KOi K03550.
OMAi RNEVFLA.
OrthoDBi EOG679THG.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00031. DNA_helic_RuvA.
InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view ]
Pfami PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view ]
SMARTi SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00084. ruvA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiRUVA_BRUME
AccessioniPrimary (citable) accession number: P66742
Secondary accession number(s): Q8YIV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi