P66697 (RPIA_STRP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	SPy_0889, M5005_Spy0695

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP-Rule MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP-Rule MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Ribose-5-phosphate isomerase A HAMAP-Rule MF_00170		PRO_0000158476

Sequences

	Sequence		Length	Mass (Da)
	P66697 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 19C4E551822EE2E2	FASTA	227	24,277
	10 20 30 40 50 60 MEALKKIAGV TAAQYVTDGM TIGLGTGSTA YYFVEEIGRR VKQEGLQVVG VTTSSVTSKQ 70 80 90 100 110 120 AEVLGIPLKS IDDIDSIDLT VDGADEVDKN FNGIKGGGAA LLMEKIVATP TKEYIWVVDA 130 140 150 160 170 180 SKMVEHLGAF KLPVEVVQYG ADRLFRVFEK AGYKPSFRMK GDSRLVTDMQ NYIIDLDLGC 190 200 210 220 IKDPVAFGHL LDGTVGVVEH GLFNGMVDKV IVASKDGVTV LEAPTAG

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK33809.1. CP000017 Genomic DNA. Translation: AAZ51313.1.
RefSeq	NP_269088.1. NC_002737.1. YP_282058.1. NC_007297.1.
3D structure databases
ProteinModelPortal	P66697.
ModBase	Search...
Protein-protein interaction databases
STRING	160490.SPy_0889.
Proteomic databases
PaxDb	P66697.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK33809; AAK33809; SPy_0889. AAZ51313; AAZ51313; M5005_Spy0695.
GeneID	3572207. 901047.
KEGG	spy:SPy_0889. spz:M5005_Spy_0695.
PATRIC	19715394. VBIStrPyo79812_0765.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0120.
HOGENOM	HOG000276369.
KO	K01807.
OMA	STTAYFI.
ProtClustDB	PRK00702.
Enzyme and pathway databases
UniPathway	UPA00115; UER00412.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A.
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. [Graphical view]
PANTHER	PTHR11934. PTHR11934. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. rpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_STRP1

Accession

Primary (citable) accession number: P66697
Secondary accession number(s): Q48ZA5, Q9A085

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program