P66653 (RIMM_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosome maturation factor rimM

Gene names

Name:	rimM
Ordered Locus Names:	Rv2907c, MT2975
ORF Names:	MTCY274.38c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after rbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes By similarity. HAMAP MF_00014
Subunit structure	Binds ribosomal protein S19 By similarity. HAMAP MF_00014
Subcellular location	Cytoplasm By similarity HAMAP MF_00014.
Domain	The PRC barrel domain binds ribosomal protein S19 By similarity. HAMAP MF_00014
Sequence similarities	Belongs to the rimM family. Contains 1 PRC barrel domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE rRNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: InterPro
Molecular function	ribosome binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Ribosome maturation factor rimM HAMAP MF_00014		PRO_0000163320
Regions
	Domain	100 – 172	73	PRC barrel

Sequences

	Sequence		Length	Mass (Da)
	P66653 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 3CB6B02306ADC420	FASTA	176	18,616
	10 20 30 40 50 60 MELVVGRVVK SHGVTGEVVV EIRTDDPADR FAPGTRLRAK GPFDGGAEGS AVSYVIESVR 70 80 90 100 110 120 QHGGRLLVRL AGVADRDAAD ALRGSLFVID ADDLPPIDEP DTYYDHQLVG LMVQTATGEG 130 140 150 160 170 VGVVTEVVHT AAGELLAVKR DSDEVLVPFV RAIVTSVSLD DGIVEIDPPH GLLNLE

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842581 Genomic DNA. Translation: CAA98344.1. AE000516 Genomic DNA. Translation: AAK47301.1.
PIR	F70927.
RefSeq	NP_217423.1. NC_000962.2. NP_337487.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P66653.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002416; EBMYCP00000002416; EBMYCG00000002414. EBMYCT00000072696; EBMYCP00000070755; EBMYCG00000072691.
GeneID	887188. 925303.
GenomeReviews	Gene locus MT2975 in contig AE000516_GR. Gene locus Rv2907c in contig AL123456_GR.
KEGG	mtc:MT2975. mtu:Rv2907c.
PATRIC	18128310. VBIMycTub22151_3254.
TIGR	MT2975.
Organism-specific databases
TubercuList	Rv2907c.
Phylogenomic databases
GeneTree	EBGT00050000017443.
HOGENOM	HBG703775.
OMA	PDEFYDH.
PhylomeDB	P66653.
ProtClustDB	PRK00122.
Family and domain databases
HAMAP	MF_00014. Ribosome_mat_RimM. [Tree]
InterPro	IPR011961. 16S_RimM. IPR007903. PRC_barrel. IPR011033. PRC_barrell-like. IPR002676. RimM. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:2.40.30.60. G3DSA:2.40.30.60. 1 hit.
KO	K02860.
Pfam	PF05239. PRC. 1 hit. PF01782. RimM. 1 hit. [Graphical view]
SUPFAM	SSF50346. PRCH_cytoplasmic. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR02273. 16S_RimM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIMM_MYCTU

Accession

Primary (citable) accession number: P66653
Secondary accession number(s): Q10824

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program