P66311 (RL6_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L6

Gene names

Name:	rplF
Ordered Locus Names:	Rv0719, MT0744
ORF Names:	MTCY210.38

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. HAMAP MF_01365_B
Subunit structure	Part of the 50S ribosomal subunit By similarity. HAMAP MF_01365_B
Sequence similarities	Belongs to the ribosomal protein L6P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE translation Inferred from electronic annotation. Source: InterPro
Cellular component	cell wall Inferred from direct assay. Source: MTBBASE plasma membrane Inferred from direct assay. Source: MTBBASE ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	50S ribosomal protein L6 HAMAP MF_01365_B		PRO_0000131062

Sequences

	Sequence		Length	Mass (Da)
	P66311 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 70C5F357B7C452E9	FASTA	179	19,377
	10 20 30 40 50 60 MSRIGKQPIP VPAGVDVTIE GQSISVKGPK GTLGLTVAEP IKVARNDDGA IVVTRPDDER 70 80 90 100 110 120 RNRSLHGLSR TLVSNLVTGV TQGYTTKMEI FGVGYRVQLK GSNLEFALGY SHPVVIEAPE 130 140 150 160 170 GITFAVQAPT KFTVSGIDKQ KVGQIAANIR RLRRPDPYKG KGVRYEGEQI RRKVGKTGK

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842574 Genomic DNA. Translation: CAB06443.1. AE000516 Genomic DNA. Translation: AAK44978.1.
PIR	B70644.
RefSeq	NP_215233.1. NC_000962.2. NP_335164.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P66311.
SMR	P66311. Positions 7-179.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000628; EBMYCP00000000628; EBMYCG00000000628. EBMYCT00000070706; EBMYCP00000068765; EBMYCG00000070701.
GeneID	888433. 926037.
GenomeReviews	Gene locus MT0744 in contig AE000516_GR. Gene locus Rv0719 in contig AL123456_GR.
KEGG	mtc:MT0744. mtu:Rv0719.
PATRIC	18123371. VBIMycTub22151_0815.
TIGR	MT0744.
Organism-specific databases
TubercuList	Rv0719.
Phylogenomic databases
GeneTree	EBGT00050000015590.
HOGENOM	HBG606796.
OMA	ALINNMV.
PhylomeDB	P66311.
ProtClustDB	PRK05498.
Family and domain databases
HAMAP	MF_01365_B. Ribosomal_L6_B. [Tree]
InterPro	IPR000702. Ribosomal_L6. IPR020040. Ribosomal_L6_a/b-dom. IPR019906. Ribosomal_L6_bac-type. IPR002358. Ribosomal_L6_CS. [Graphical view]
Gene3D	G3DSA:3.90.930.12. Ribosomal_L6. 2 hits.
KO	K02933.
PANTHER	PTHR11655:SF6. PTHR11655:SF6. 1 hit. PTHR11655. Ribosomal_L6. 1 hit.
Pfam	PF00347. Ribosomal_L6. 2 hits. [Graphical view]
PIRSF	PIRSF002162. Ribosomal_L6. 1 hit.
PRINTS	PR00059. RIBOSOMALL6.
SUPFAM	SSF56053. Ribosomal_L6. 2 hits.
TIGRFAMs	TIGR03654. L6_bact. 1 hit.
PROSITE	PS00525. RIBOSOMAL_L6_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL6_MYCTU

Accession

Primary (citable) accession number: P66311
Secondary accession number(s): P95067

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program