P66117 (RL21_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L21

Gene names

Name:	rplU
Ordered Locus Names:	Rv2442c, MT2518
ORF Names:	MTCY428.04

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein binds to 23S rRNA in the presence of protein L20 By similarity. HAMAP MF_01363
Subunit structure	Part of the 50S ribosomal subunit. Contacts protein L20 By similarity.
Sequence similarities	Belongs to the ribosomal protein L21P family.
Sequence caution	The sequence AAK46815.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB03777.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE translation Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from direct assay. Source: MTBBASE ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	50S ribosomal protein L21 HAMAP MF_01363		PRO_0000181010

Sequences

	Sequence		Length	Mass (Da)
	P66117 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: 3E9E45AD44402E6A	FASTA	103	11,020
	10 20 30 40 50 60 MATYAIVKTG GKQYKVAVGD VVKVEKLESE QGEKVSLPVA LVVDGATVTT DAKALAKVAV 70 80 90 100 TGEVLGHTKG PKIRIHKFKN KTGYHKRQGH RQQLTVLKVT GIA

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842579 Genomic DNA. Translation: CAB03777.1. Different initiation. AE000516 Genomic DNA. Translation: AAK46815.1. Different initiation.
PIR	H70680.
RefSeq	NP_216958.1. NC_000962.2. NP_337001.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P66117.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001966; EBMYCP00000001966; EBMYCG00000001964. EBMYCT00000071217; EBMYCP00000069276; EBMYCG00000071212.
GeneID	885715. 925818.
GenomeReviews	Gene locus MT2518 in contig AE000516_GR. Gene locus Rv2442c in contig AL123456_GR.
KEGG	mtc:MT2518. mtu:Rv2442c.
PATRIC	18127286. VBIMycTub22151_2751.
TIGR	MT2518.
Organism-specific databases
TubercuList	Rv2442c.
Phylogenomic databases
GeneTree	EBGT00050000017407.
HOGENOM	HBG706775.
OMA	IKVEQIA.
PhylomeDB	P66117.
ProtClustDB	PRK05573.
Family and domain databases
HAMAP	MF_01363. Ribosomal_L21. [Tree]
InterPro	IPR001787. Ribosomal_L21. IPR018258. Ribosomal_L21_CS. [Graphical view]
KO	K02888.
PANTHER	PTHR21349. Ribosomal_L21p. 1 hit.
Pfam	PF00829. Ribosomal_L21p. 1 hit. [Graphical view]
TIGRFAMs	TIGR00061. L21. 1 hit.
PROSITE	PS01169. RIBOSOMAL_L21. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL21_MYCTU

Accession

Primary (citable) accession number: P66117
Secondary accession number(s): P71907

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program