P66056 (RL11_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L11

Gene names

Name:	rplK
Ordered Locus Names:	Rv0640, MT0669
ORF Names:	MTCY20H11.21

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein binds directly to 23S ribosomal RNA By similarity. HAMAP-Rule MF_00736_B
Post-translational modification	One or more lysine residues are methylated By similarity.
Sequence similarities	Belongs to the ribosomal protein L11P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Isopeptide bond Methylation Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	growth Inferred from mutant phenotype PubMed 12657046. Source: MTBBASE translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cell wall Inferred from direct assay PubMed 15525680. Source: MTBBASE ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	50S ribosomal protein L11 HAMAP-Rule MF_00736_B		PRO_0000104325
Amino acid modifications
	Cross-link	101		Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) HAMAP-Rule MF_00736_B

Sequences

	Sequence		Length	Mass (Da)
	P66056 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 6601A28FC4581455	FASTA	142	15,003
	10 20 30 40 50 60 MAPKKKVAGL IKLQIVAGQA NPAPPVGPAL GQHGVNIMEF CKAYNAATEN QRGNVIPVEI 70 80 90 100 110 120 TVYEDRSFTF TLKTPPAAKL LLKAAGVAKG SAEPHKTKVA KVTWDQVREI AETKKTDLNA 130 140 NDVDAAAKII AGTARSMGIT VE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis." Festa R.A., McAllister F., Pearce M.J., Mintseris J., Burns K.E., Gygi S.P., Darwin K.H. PLoS ONE 5:E8589-E8589(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PUPYLATION AT LYS-101, IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 25618 / H37Rv.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842574 Genomic DNA. Translation: CAB07099.1. AE000516 Genomic DNA. Translation: AAK44894.1. AL123456 Genomic DNA. Translation: CCP43383.1.
PIR	E70613.
RefSeq	NP_215154.1. NC_000962.3. NP_335080.1. NC_002755.2. YP_006513981.1. NC_018143.1.
3D structure databases
ProteinModelPortal	P66056.
SMR	P66056. Positions 5-141.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv0640.
Proteomic databases
PRIDE	P66056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK44894; AAK44894; MT0669.
GeneID	13318526. 888045. 925952.
KEGG	mtc:MT0669. mtu:Rv0640. mtv:RVBD_0640.
PATRIC	18123193. VBIMycTub22151_0726.
Organism-specific databases
TubercuList	Rv0640.
Phylogenomic databases
eggNOG	COG0080.
HOGENOM	HOG000082123.
KO	K02867.
OMA	KQFNAKT.
ProtClustDB	PRK00140.
Family and domain databases
Gene3D	1.10.10.250. 1 hit. 3.30.1550.10. 1 hit.
HAMAP	MF_00736_B. Ribosomal_L11_B.
InterPro	IPR000911. Ribosomal_L11. IPR006519. Ribosomal_L11_bac-typ. IPR020783. Ribosomal_L11_C. IPR020785. Ribosomal_L11_CS. IPR020784. Ribosomal_L11_N. [Graphical view]
PANTHER	PTHR11661. PTHR11661. 1 hit.
Pfam	PF00298. Ribosomal_L11. 1 hit. PF03946. Ribosomal_L11_N. 1 hit. [Graphical view]
SMART	SM00649. RL11. 1 hit. [Graphical view]
SUPFAM	SSF46906. Ribosomal_L11. 1 hit. SSF54747. Ribosomal_L11. 1 hit.
TIGRFAMs	TIGR01632. L11_bact. 1 hit.
PROSITE	PS00359. RIBOSOMAL_L11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL11_MYCTU

Accession

Primary (citable) accession number: P66056
Secondary accession number(s): L0T752, P96931

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program