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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (ribD)
  3. Riboflavin biosynthesis protein RibD (ribD)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Zinc; catalyticUniRule annotation1
Metal bindingi65Zinc; catalyticUniRule annotation1
Metal bindingi67Zinc; catalyticUniRule annotation1
Binding sitei70GTPUniRule annotation1
Binding sitei114GTPUniRule annotation1
Active sitei126Proton acceptorUniRule annotation1
Active sitei128NucleophileUniRule annotation1
Binding sitei149GTPUniRule annotation1
Binding sitei154GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 53GTPUniRule annotation5
Nucleotide bindingi92 – 94GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processRiboflavin biosynthesis
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1728-MONOMER
UniPathwayiUPA00275; UER00400

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotation
Ordered Locus Names:STM1711
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001517741 – 196GTP cyclohydrolase-2Add BLAST196

Proteomic databases

PaxDbiP66030
PRIDEiP66030

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1711

Structurei

3D structure databases

ProteinModelPortaliP66030
SMRiP66030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T1C Bacteria
COG0807 LUCA
HOGENOMiHOG000115442
KOiK01497
OMAiGQGFILY
PhylomeDBiP66030

Family and domain databases

CDDicd00641 GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179 RibA, 1 hit
InterProiView protein in InterPro
IPR032677 GTP_cyclohydro_II
IPR000926 RibA
IPR036144 RibA-like_sf
PfamiView protein in Pfam
PF00925 GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695 SSF142695, 1 hit
TIGRFAMsiTIGR00505 ribA, 1 hit

Sequencei

Sequence statusi: Complete.

P66030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKRVAEAK LPTPLGDFLM VGFEELATGH DHAALVFGDI SGKTPVLARV
60 70 80 90 100
HSECLTGDAL FSLRCDCGFQ LEAALTHIAE EGRGILIYHR QEGRNIGLLN
110 120 130 140 150
KIRAYALQDQ GYDTVEANHQ LGFAADERDF TLCADMFKLL GVDEVRLLTN
160 170 180 190
NPKKVEILTE AGINIVERVP LIVGRNPNNE HYLDTKAAKM GHLLSK
Length:196
Mass (Da):21,635
Last modified:October 11, 2004 - v1
Checksum:i716789508B71502D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL20629.1
RefSeqiNP_460670.1, NC_003197.2
WP_001176284.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20629; AAL20629; STM1711
GeneIDi1253230
KEGGistm:STM1711
PATRICifig|99287.12.peg.1806

Similar proteinsi

Entry informationi

Entry nameiRIBA_SALTY
AccessioniPrimary (citable) accession number: P66030
Secondary accession number(s): Q8XFY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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