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P66015

- RELA_MYCBO

UniProt

P66015 - RELA_MYCBO

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Protein
Probable GTP pyrophosphokinase
Gene
relA, Mb2614c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. amino acid binding Source: InterPro
  5. kinase activity Source: UniProtKB-KW
  6. metal ion binding Source: InterPro
  7. phosphoric diester hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Ordered Locus Names:Mb2614c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Probable GTP pyrophosphokinase
PRO_0000166552Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2614c.

Structurei

3D structure databases

ProteinModelPortaliP66015.
SMRiP66015. Positions 65-397, 450-513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 20298HD
Add
BLAST
Domaini714 – 78875ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
OMAiRDFADIY.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P66015-1 [UniParc]FASTAAdd to Basket

« Hide

MAEDQLTAQA VAPPTEASAA LEPALETPES PVETLKTSIS ASRRVRARLA    50
RRMTAQRSTT NPVLEPLVAV HREIYPKADL SILQRAYEVA DQRHASQLRQ 100
SGDPYITHPL AVANILAELG MDTTTLVAAL LHDTVEDTGY TLEALTEEFG 150
EEVGHLVDGV TKLDRVVLGS AAEGETIRKM ITAMARDPRV LVIKVADRLH 200
NMRTMRFLPP EKQARKARET LEVIAPLAHR LGMASVKWEL EDLSFAILHP 250
KKYEEIVRLV AGRAPSRDTY LAKVRAEIVN TLTASKIKAT VEGRPKHYWS 300
IYQKMIVKGR DFDDIHDLVG VRILCDEIRD CYAAVGVVHS LWQPMAGRFK 350
DYIAQPRYGV YQSLHTTVVG PEGKPLEVQI RTRDMHRTAE YGIAAHWRYK 400
EAKGRNGVLH PHAAAEIDDM AWMRQLLDWQ REAADPGEFL ESLRYDLAVQ 450
EIFVFTPKGD VITLPTGSTP VDFAYAVHTE VGHRCIGARV NGRLVALERK 500
LENGEVVEVF TSKAPNAGPS RDWQQFVVSP RAKTKIRQWF AKERREEALE 550
TGKDAMAREV RRGGLPLQRL VNGESMAAVA RELHYADVSA LYTAIGEGHV 600
SAKHVVQRLL AELGGIDQAE EELAERSTPA TMPRRPRSTD DVGVSVPGAP 650
GVLTKLAKCC TPVPGDVIMG FVTRGGGVSV HRTDCTNAAS LQQQAERIIE 700
VLWAPSPSSV FLVAIQVEAL DRHRLLSDVT RALADEKVNI LSASVTTSGD 750
RVAISRFTFE MGDPKHLGHL LNAVRNVEGV YDVYRVTSAA 790
Length:790
Mass (Da):87,354
Last modified:October 11, 2004 - v1
Checksum:i7A7E669241C0E299
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43878.1.
RefSeqiNP_856260.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94799; CAD94799; Mb2614c.
GeneIDi1092024.
KEGGimbo:Mb2614c.
PATRICi18007477. VBIMycBov88188_2875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43878.1 .
RefSeqi NP_856260.1. NC_002945.3.

3D structure databases

ProteinModelPortali P66015.
SMRi P66015. Positions 65-397, 450-513.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233413.Mb2614c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94799 ; CAD94799 ; Mb2614c .
GeneIDi 1092024.
KEGGi mbo:Mb2614c.
PATRICi 18007477. VBIMycBov88188_2875.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
OMAi RDFADIY.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiRELA_MYCBO
AccessioniPrimary (citable) accession number: P66015
Secondary accession number(s): Q50638, X2BLD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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