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P66015

- RELA_MYCBO

UniProt

P66015 - RELA_MYCBO

Protein

Probable GTP pyrophosphokinase

Gene

relA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.By similarity

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. GTP binding Source: UniProtKB-KW
    4. GTP diphosphokinase activity Source: UniProtKB-EC
    5. kinase activity Source: UniProtKB-KW
    6. metal ion binding Source: InterPro
    7. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable GTP pyrophosphokinase (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase
    ATP:GTP 3'-pyrophosphotransferase
    ppGpp synthase I
    Gene namesi
    Name:relA
    Ordered Locus Names:Mb2614c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 790790Probable GTP pyrophosphokinasePRO_0000166552Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2614c.

    Structurei

    3D structure databases

    ProteinModelPortaliP66015.
    SMRiP66015. Positions 65-397, 450-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 20298HDAdd
    BLAST
    Domaini714 – 78875ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOGENOMiHOG000018301.
    KOiK00951.
    OMAiRDFADIY.
    OrthoDBiEOG6SV551.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P66015-1 [UniParc]FASTAAdd to Basket

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    MAEDQLTAQA VAPPTEASAA LEPALETPES PVETLKTSIS ASRRVRARLA    50
    RRMTAQRSTT NPVLEPLVAV HREIYPKADL SILQRAYEVA DQRHASQLRQ 100
    SGDPYITHPL AVANILAELG MDTTTLVAAL LHDTVEDTGY TLEALTEEFG 150
    EEVGHLVDGV TKLDRVVLGS AAEGETIRKM ITAMARDPRV LVIKVADRLH 200
    NMRTMRFLPP EKQARKARET LEVIAPLAHR LGMASVKWEL EDLSFAILHP 250
    KKYEEIVRLV AGRAPSRDTY LAKVRAEIVN TLTASKIKAT VEGRPKHYWS 300
    IYQKMIVKGR DFDDIHDLVG VRILCDEIRD CYAAVGVVHS LWQPMAGRFK 350
    DYIAQPRYGV YQSLHTTVVG PEGKPLEVQI RTRDMHRTAE YGIAAHWRYK 400
    EAKGRNGVLH PHAAAEIDDM AWMRQLLDWQ REAADPGEFL ESLRYDLAVQ 450
    EIFVFTPKGD VITLPTGSTP VDFAYAVHTE VGHRCIGARV NGRLVALERK 500
    LENGEVVEVF TSKAPNAGPS RDWQQFVVSP RAKTKIRQWF AKERREEALE 550
    TGKDAMAREV RRGGLPLQRL VNGESMAAVA RELHYADVSA LYTAIGEGHV 600
    SAKHVVQRLL AELGGIDQAE EELAERSTPA TMPRRPRSTD DVGVSVPGAP 650
    GVLTKLAKCC TPVPGDVIMG FVTRGGGVSV HRTDCTNAAS LQQQAERIIE 700
    VLWAPSPSSV FLVAIQVEAL DRHRLLSDVT RALADEKVNI LSASVTTSGD 750
    RVAISRFTFE MGDPKHLGHL LNAVRNVEGV YDVYRVTSAA 790
    Length:790
    Mass (Da):87,354
    Last modified:October 11, 2004 - v1
    Checksum:i7A7E669241C0E299
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43878.1.
    RefSeqiNP_856260.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD94799; CAD94799; Mb2614c.
    GeneIDi1092024.
    KEGGimbo:Mb2614c.
    PATRICi18007477. VBIMycBov88188_2875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43878.1 .
    RefSeqi NP_856260.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P66015.
    SMRi P66015. Positions 65-397, 450-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2614c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD94799 ; CAD94799 ; Mb2614c .
    GeneIDi 1092024.
    KEGGi mbo:Mb2614c.
    PATRICi 18007477. VBIMycBov88188_2875.

    Phylogenomic databases

    eggNOGi COG0317.
    HOGENOMi HOG000018301.
    KOi K00951.
    OMAi RDFADIY.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiRELA_MYCBO
    AccessioniPrimary (citable) accession number: P66015
    Secondary accession number(s): Q50638, X2BLD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3