ID   Y718_BRUME              Reviewed;         249 AA.
AC   P65955; Q8YHS8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=UPF0758 protein BMEI0718;
GN   OrderedLocusNames=BMEI0718;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
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DR   EMBL; AE008917; AAL51899.1; -; Genomic_DNA.
DR   PIR; AH3341; AH3341.
DR   RefSeq; WP_002964401.1; NZ_GG703780.1.
DR   AlphaFoldDB; P65955; -.
DR   SMR; P65955; -.
DR   GeneID; 58775648; -.
DR   KEGG; bme:BMEI0718; -.
DR   KEGG; bmel:DK63_709; -.
DR   PATRIC; fig|224914.52.peg.740; -.
DR   eggNOG; COG2003; Bacteria.
DR   PhylomeDB; P65955; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd08071; MPN_DUF2466; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR025657; RadC_JAB.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001405; UPF0758.
DR   InterPro; IPR020891; UPF0758_CS.
DR   NCBIfam; TIGR00608; radc; 1.
DR   PANTHER; PTHR30471; DNA REPAIR PROTEIN RADC; 1.
DR   PANTHER; PTHR30471:SF3; UPF0758 PROTEIN YEES-RELATED; 1.
DR   Pfam; PF04002; RadC; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50249; MPN; 1.
DR   PROSITE; PS01302; UPF0758; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Zinc.
FT   CHAIN           1..249
FT                   /note="UPF0758 protein BMEI0718"
FT                   /id="PRO_0000190688"
FT   DOMAIN          127..249
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           198..211
FT                   /note="JAMM motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         200
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   BINDING         211
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   249 AA;  27676 MW;  0DF77325A6F0638D CRC64;
     MAKKKDTPGD GEFPGFSDTL QRTPKLEKPH YAGHRDRLKQ RFRDAPDALA DYELLELLLF
     RAIRRADTKP IAKALLNRFG SIAEVLAAPE NLIAEIPGAG PTVALELKLV EAIAKRSARS
     TVMEREVLGS WDKVINYCTA AMAFETREQF RILFLDKKNK LIADEVQQTG TVDHTPVYPR
     EVVKRALELS ATAIILVHNH PSGDPTPSRA DIDMTKQLVN AAKALNITVH DHVIIGKHGH
     ASLRSLRLI
//