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P65948

- QUEA_BRUME

UniProt

P65948 - QUEA_BRUME

Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. isomerase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
    Alternative name(s):
    Queuosine biosynthesis protein QueAUniRule annotation
    Gene namesi
    Name:queAUniRule annotation
    Ordered Locus Names:BMEI0889
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000165386Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI0889.

    Structurei

    3D structure databases

    ProteinModelPortaliP65948.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the QueA family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000004401.
    KOiK07568.
    OMAiDVTTHKM.
    OrthoDBiEOG6X6RBB.

    Family and domain databases

    HAMAPiMF_00113. QueA.
    InterProiIPR003699. QueA.
    [Graphical view]
    PfamiPF02547. Queuosine_synth. 1 hit.
    [Graphical view]
    SUPFAMiSSF111337. SSF111337. 1 hit.
    TIGRFAMsiTIGR00113. queA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P65948-1 [UniParc]FASTAAdd to Basket

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    MRVDLFDFDL PEERIALRPV EPRDHAKLLH VRPGEPFEDR HVYDLPDLLQ    50
    PGDALVFNDT KVIPAQLEGM RERTGNISQV SATLHMRVGP DRWKAFLRPA 100
    KRVKEGDRIR FGHSGTSCFL GTLDATVAEK GDSGEALLVF DLSGAVLDEA 150
    IAAVGHIPLP PYIASKRPED ERDRKDYQTV YAREEGAVAA PTAGLHFTPD 200
    LLEKIKARGI EEHFVTLHVG AGTFLPVKAD DTGDHKMHAE IGHVSQRTAS 250
    ALNAVHERGG RIICVGTTSL RLIESATGED GVVRPWSGAT DIFITPGYRF 300
    RAVDLLMTNF HLPRSTLFML VSAFSGLDTM HAAYNYAIAD GYRFYSYGDA 350
    SLLERIDHDR HSA 363
    Length:363
    Mass (Da):40,174
    Last modified:October 11, 2004 - v1
    Checksum:i972A658AA3E91CFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52070.1.
    PIRiAC3363.
    RefSeqiNP_539806.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52070; AAL52070; BMEI0889.
    GeneIDi1196600.
    KEGGibme:BMEI0889.
    PATRICi17801966. VBIBruMel146950_3303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52070.1 .
    PIRi AC3363.
    RefSeqi NP_539806.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali P65948.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52070 ; AAL52070 ; BMEI0889 .
    GeneIDi 1196600.
    KEGGi bme:BMEI0889.
    PATRICi 17801966. VBIBruMel146950_3303.

    Phylogenomic databases

    HOGENOMi HOG000004401.
    KOi K07568.
    OMAi DVTTHKM.
    OrthoDBi EOG6X6RBB.

    Enzyme and pathway databases

    UniPathwayi UPA00392 .

    Family and domain databases

    HAMAPi MF_00113. QueA.
    InterProi IPR003699. QueA.
    [Graphical view ]
    Pfami PF02547. Queuosine_synth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111337. SSF111337. 1 hit.
    TIGRFAMsi TIGR00113. queA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiQUEA_BRUME
    AccessioniPrimary (citable) accession number: P65948
    Secondary accession number(s): Q8YHB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3