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Reviewed, UniProtKB/Swiss-Prot P65898 (PURK_MYCTU)

Last modified November 3, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phosphoribosylaminoimidazole carboxylase ATPase subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC
Gene names
Name: purK
Ordered Locus Names: Rv3276c, MT3376
ORF Names: MTCY71.16c
OrganismMycobacterium tuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

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Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition By similarity.

Catalytic activity

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purK/purT family.

Contains 1 ATP-grasp domain.

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Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazole carboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Phosphoribosylaminoimidazole carboxylase ATPase subunit
PRO_0000075000

Regions

Domain121 – 310190ATP-grasp
Nucleotide binding194 – 1974ATP By similarity
Nucleotide binding280 – 2812ATP By similarity

Sites

Binding site1171ATP By similarity
Binding site1571ATP By similarity
Binding site2021ATP By similarity

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Sequences

Sequence LengthMass (Da)Tools
P65898-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1A80B4CCAB8CB13E

FASTA42945,695
        10         20         30         40         50         60 
MMAVASSRTP AVTSFIAPLV AMVGGGQLAR MTHQAAIALG QNLRVLVTSA DDPAAQVTPN 

        70         80         90        100        110        120 
VVIGSHTDLA ALRRVAAGAD VLTFDHEHVP NELLEKLVAD GVNVAPSPQA LVHAQDKLVM 

       130        140        150        160        170        180 
RQRLAAAGVA VPRYAGIKDP DEIDVFAARV DAPIVVKAVR GGYDGRGVRM ARDVADARDF 

       190        200        210        220        230        240 
ARECLADGVA VLVEERVDLR RELSALVARS PFGQGAAWPV VQTVQRDGTC VLVIAPAPAL 

       250        260        270        280        290        300 
PDDLATAAQR LALQLADELG VVGVLAVELF ETTDGALLVN ELAMRPHNSG HWTIDGARTS 

       310        320        330        340        350        360 
QFEQHLRAVL DYPLGDSDAV VPVTVMANVL GAAQPPAMSV DERLHHLFAR MPDARVHLYG 

       370        380        390        400        410        420 
KAERPGRKVG HINFLGSDVA QLCERAELAA HWLSHGRWTD GWDPHRASDD AVGVPPACGG 


RSDEEERRL

« Hide

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Cross-references

Sequence databases

BX842582 Genomic DNA. Translation: CAB07079.1.
AE000516 Genomic DNA. Translation: AAK47717.1.
PIRE70979.
RefSeqNP_217793.1.
NP_337903.1.

3D structure databases

HSSPHSSP built from PDB template 1B6R based on UniProtKB P09029.
ModBaseSearch...

Genome annotation databases

GeneID888720.
922458.
GenomeReviewsGene locus MT3376 in contig AE000516_GR.
Gene locus Rv3276c in contig AL123456_GR.
KEGGmtc:MT3376.
mtu:Rv3276c.
TIGRMT3376.

Organism-specific databases

TubercuListRv3276c.

Phylogenomic databases

HOGENOMP65898.
OMARKIGHVN.

Enzyme and pathway databases

BRENDA4.1.1.21. 809.

Family and domain databases

InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR013817. Pre-ATP_grasp.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PANTHERPTHR23047:SF1. PurK_ATP. 1 hit.
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
TIGRFAMsTIGR01161. purK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePURK_MYCTU
AccessionPrimary (citable) accession number: P65898
Secondary accession number(s): P96881
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents