Reviewed,
UniProtKB/Swiss-Prot P65897 (PUR3_STAAM)
Last modified
November 3, 2009.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphoribosylglycinamide formyltransferase EC=2.1.2.2 Alternative name(s): 5'-phosphoribosylglycinamide transformylase GAR transformylase Short name=GART | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 158878 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the GART family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | phosphoribosylglycinamide formyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Phosphoribosylglycinamide formyltransferase | PRO_0000074946 | |||||
Regions | |||||||||
| Region | 12 – 14 | 3 | 5'-phosphoribosylglycinamide binding By similarity | ||||||
| Region | 91 – 94 | 4 | 10-formyltetrahydrofolate binding By similarity | ||||||
Sites | |||||||||
| Active site | 110 | 1 | Proton donor By similarity | ||||||
| Binding site | 66 | 1 | 10-formyltetrahydrofolate By similarity | ||||||
| Binding site | 108 | 1 | 10-formyltetrahydrofolate By similarity | ||||||
| Binding site | 146 | 1 | 10-formyltetrahydrofolate; via amide nitrogen By similarity | ||||||
| Binding site | 175 | 1 | 5'-phosphoribosylglycinamide By similarity | ||||||
| Site | 146 | 1 | Raises pKa of active site His By similarity | ||||||
Sequences
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References
| [1] | "Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. Hiramatsu K.Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| BA000017 Genomic DNA. Translation: BAB57234.1. | |
| RefSeq | NP_371596.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GAR based on UniProtKB P08179. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P65897. |
2-D gel databases | |
| World-2DPAGE | 0002:P65897. |
Genome annotation databases | |
| GeneID | 1121049. |
| GenomeReviews | Gene locus SAV1072 in contig BA000017_GR. |
| KEGG | sav:SAV1072. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P65897. |
| OMA | CSVHFVT. |
Enzyme and pathway databases | |
| BioCyc | SAUR158878:SAV1072-MON. |
Family and domain databases | |
| InterPro | IPR002376. Formyl_transf_N. IPR001555. GART_AS. IPR004607. PurN_trans. [Graphical view] |
| Gene3D | G3DSA:3.40.50.170. Formyl_transf_N. 1 hit. |
| Pfam | PF00551. Formyl_trans_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00639. PurN. 1 hit. |
| PROSITE | PS00373. GART. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR3_STAAM | ||||||||
| Accession | Primary (citable) accession number: P65897 Secondary accession number(s): Q99V25 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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