Skip Header

Contribute Send feedback
Read comments (?) or add your own

P65865 (PTH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:Rv1014c, MT1042
ORF Names:MTCY10G2.35
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083

Subunit structure

Monomer By similarity. HAMAP MF_00083

Subcellular location

Cytoplasm By similarity HAMAP MF_00083.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgrowth

Inferred from mutant phenotype. Source: MTBBASE

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionaminoacyl-tRNA hydrolase activity

Inferred from direct assay. Source: MTBBASE

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Peptidyl-tRNA hydrolase HAMAP MF_00083
PRO_0000187780

Secondary structure

1 .................................. 191
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P65865 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1826278CBBA170BD

FASTA19120,456
        10         20         30         40         50         60 
MAEPLLVVGL GNPGANYART RHNLGFVVAD LLAARLGAKF KAHKRSGAEV ATGRSAGRSL 

        70         80         90        100        110        120 
VLAKPRCYMN ESGRQIGPLA KFYSVAPANI IVIHDDLDLE FGRIRLKIGG GEGGHNGLRS 

       130        140        150        160        170        180 
VVAALGTKDF QRVRIGIGRP PGRKDPAAFV LENFTPAERA EVPTICEQAA DATELLIEQG 

       190 
MEPAQNRVHA W

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAB06865.1.
AE000516 Genomic DNA. Translation: AAK45293.1.
PIRA70622.
RefSeqNP_215530.1. NC_000962.2.
NP_335479.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JRCNMR-A1-191[»]
2Z2IX-ray1.98A1-191[»]
2Z2JX-ray2.35A/B1-191[»]
2Z2KX-ray2.50A1-191[»]
ProteinModelPortalP65865.
SMRP65865. Positions 1-191.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001706; EBMYCP00000001706; EBMYCG00000001705.
EBMYCT00000072150; EBMYCP00000070209; EBMYCG00000072145.
GeneID886037.
925158.
GenomeReviewsGene locus MT1042 in contig AE000516_GR.
Gene locus Rv1014c in contig AL123456_GR.
KEGGmtc:MT1042.
mtu:Rv1014c.
PATRIC18124034. VBIMycTub22151_1139.
TIGRMT1042.

Organism-specific databases

TubercuListRv1014c.

Phylogenomic databases

GeneTreeEBGT00050000017462.
HOGENOMHBG610927.
OMAIKFKTGG.
PhylomeDBP65865.
ProtClustDBPRK05426.

Family and domain databases

HAMAPMF_00083. Pept_tRNA_hydro_bact.
[Tree]
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KOK01056.
PANTHERPTHR17224. Pept_tRNA_hydro. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMsTIGR00447. Pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_MYCTU
AccessionPrimary (citable) accession number: P65865
Secondary accession number(s): P96386
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents