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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-606-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SAV0588
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Phosphate acetyltransferasePRO_0000179141Add
BLAST

2D gel databases

World-2DPAGE0002:P65862.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0588.

Structurei

3D structure databases

ProteinModelPortaliP65862.
SMRiP65862. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053796.
KOiK00625.
OMAiYEGFEEM.
OrthoDBiEOG6BKJ5W.
PhylomeDBiP65862.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

P65862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLLNVLKD KLSGKNVKIV LPEGEDERVL TAATQLQATD YVTPIVLGDE
60 70 80 90 100
TKVQSLAQKL DLDISNIELI NPATSELKAE LVQSFVERRK GKATEEQAQE
110 120 130 140 150
LLNNVNYFGT MLVYAGKADG LVSGAAHSTG DTVRPALQII KTKPGVSRTS
160 170 180 190 200
GIFFMIKGDE QYIFGDCAIN PELDSQGLAE IAVESAKSAL SFGMDPKVAM
210 220 230 240 250
LSFSTKGSAK SDDVTKVQEA VKLAQQKAEE EKLEAIIDGE FQFDAAIVPG
260 270 280 290 300
VAEKKAPGAK LQGDANVFVF PSLEAGNIGY KIAQRLGGYD AVGPVLQGLN
310 320
SPVNDLSRGC SIEDVYNLSI ITAAQALQ
Length:328
Mass (Da):34,952
Last modified:October 11, 2004 - v1
Checksum:i7EBE5837CEB3D188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56750.1.
RefSeqiNP_371112.1. NC_002758.2.
WP_000774281.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56750; BAB56750; SAV0588.
KEGGisav:SAV0588.
PATRICi19561830. VBIStaAur52173_0595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56750.1.
RefSeqiNP_371112.1. NC_002758.2.
WP_000774281.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP65862.
SMRiP65862. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0588.

2D gel databases

World-2DPAGE0002:P65862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56750; BAB56750; SAV0588.
KEGGisav:SAV0588.
PATRICi19561830. VBIStaAur52173_0595.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053796.
KOiK00625.
OMAiYEGFEEM.
OrthoDBiEOG6BKJ5W.
PhylomeDBiP65862.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciSAUR158878:GJJ5-606-MONOMER.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiPTAS_STAAM
AccessioniPrimary (citable) accession number: P65862
Secondary accession number(s): Q99W23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 24, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.