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P65861

- CRTB_MYCBO

UniProt

P65861 - CRTB_MYCBO

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Protein

Phytoene synthase

Gene

crtB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).Curated

Cofactori

Protein has several cofactor binding sites:
  • ATPBy similarityNote: ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction.By similarity
  • Mn2+By similarity, Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
Synonyms:phyA
Ordered Locus Names:Mb3430c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Phytoene synthasePRO_0000067432Add
BLAST

Proteomic databases

PRIDEiP65861.

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3430c.

Structurei

3D structure databases

ProteinModelPortaliP65861.
SMRiP65861. Positions 1-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Phylogenomic databases

eggNOGiCOG1562.
HOGENOMiHOG000220849.
KOiK02291.
OMAiICAPDEP.
OrthoDBiEOG63FW00.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR017828. Squalene/phytoene_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03465. HpnD. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65861-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV
60 70 80 90 100
ADGELAPETK ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA
110 120 130 140 150
ELIDGARMEI DWTGCRDFDE LIVYCRRGAG TIGKLCLSIF GPVSTATSRY
160 170 180 190 200
AEQLGIALQQ TNILRDVRED FLNGRIYLPR DELDRLGVRL RLDDTGALDD
210 220 230 240 250
PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA MSGIYRRQLA
260 270 280 290 300
LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP

SH
Length:302
Mass (Da):33,142
Last modified:October 11, 2004 - v1
Checksum:iC214605A7B93AFFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44702.1.
RefSeqiNP_857071.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD95618; CAD95618; Mb3430c.
GeneIDi1090989.
KEGGimbo:Mb3430c.
PATRICi18009274. VBIMycBov88188_3765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44702.1 .
RefSeqi NP_857071.1. NC_002945.3.

3D structure databases

ProteinModelPortali P65861.
SMRi P65861. Positions 1-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3430c.

Proteomic databases

PRIDEi P65861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD95618 ; CAD95618 ; Mb3430c .
GeneIDi 1090989.
KEGGi mbo:Mb3430c.
PATRICi 18009274. VBIMycBov88188_3765.

Phylogenomic databases

eggNOGi COG1562.
HOGENOMi HOG000220849.
KOi K02291.
OMAi ICAPDEP.
OrthoDBi EOG63FW00.

Enzyme and pathway databases

UniPathwayi UPA00799 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR017828. Squalene/phytoene_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03465. HpnD. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiCRTB_MYCBO
AccessioniPrimary (citable) accession number: P65861
Secondary accession number(s): Q50728, X2BN51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3