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Protein

Phytoene synthase

Gene

crtB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).Curated

Cofactori

Protein has several cofactor binding sites:
  • ATPBy similarityNote: ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction.By similarity
  • Mn2+By similarity, Mg2+By similarity

Pathwayi: phytoene biosynthesis

This protein is involved in the pathway phytoene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarotenoid biosynthesis
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3606-MONOMER
UniPathwayiUPA00799

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
Synonyms:phyA
Ordered Locus Names:BQ2027_MB3430C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674321 – 302Phytoene synthaseAdd BLAST302

Proteomic databases

PRIDEiP65861

Structurei

3D structure databases

ProteinModelPortaliP65861
SMRiP65861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000220849
OMAiCRVADDA

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR017828 SQ_synth_HpnD-like
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR03465 HpnD, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P65861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV
60 70 80 90 100
ADGELAPETK ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA
110 120 130 140 150
ELIDGARMEI DWTGCRDFDE LIVYCRRGAG TIGKLCLSIF GPVSTATSRY
160 170 180 190 200
AEQLGIALQQ TNILRDVRED FLNGRIYLPR DELDRLGVRL RLDDTGALDD
210 220 230 240 250
PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA MSGIYRRQLA
260 270 280 290 300
LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP

SH
Length:302
Mass (Da):33,142
Last modified:October 11, 2004 - v1
Checksum:iC214605A7B93AFFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU02059.1
RefSeqiNP_857071.1, NC_002945.3
WP_003417954.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44702; CDO44702; Mb3430c
PATRICifig|233413.5.peg.3765

Similar proteinsi

Entry informationi

Entry nameiCRTB_MYCBO
AccessioniPrimary (citable) accession number: P65861
Secondary accession number(s): A0A1R3Y446, Q50728, X2BN51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health