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P65861 (CRTB_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phytoene synthase

Short name=PSase
EC=2.5.1.-
Gene names
Name:crtB
Synonyms:phyA
Ordered Locus Names:Mb3430c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene Probable.

Cofactor

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.

Manganese or magnesium By similarity.

Pathway

Carotenoid biosynthesis; phytoene biosynthesis.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Phytoene synthase
PRO_0000067432

Sequences

Sequence LengthMass (Da)Tools
P65861 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C214605A7B93AFFD

FASTA30233,142
        10         20         30         40         50         60 
MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV ADGELAPETK 

        70         80         90        100        110        120 
ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA ELIDGARMEI DWTGCRDFDE 

       130        140        150        160        170        180 
LIVYCRRGAG TIGKLCLSIF GPVSTATSRY AEQLGIALQQ TNILRDVRED FLNGRIYLPR 

       190        200        210        220        230        240 
DELDRLGVRL RLDDTGALDD PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA 

       250        260        270        280        290        300 
MSGIYRRQLA LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP 


SH 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248346 Genomic DNA. Translation: CAD95618.1.
RefSeqNP_857071.1. NC_002945.3.

3D structure databases

ProteinModelPortalP65861.
SMRP65861. Positions 1-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3430c.

Proteomic databases

PRIDEP65861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD95618; CAD95618; Mb3430c.
GeneID1090989.
KEGGmbo:Mb3430c.
PATRIC18009274. VBIMycBov88188_3765.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000220849.
KOK02291.
OMARKFWLAW.
OrthoDBEOG63FW00.
ProtClustDBCLSK872176.

Enzyme and pathway databases

UniPathwayUPA00799.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR017828. Squalene/phytoene_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03465. HpnD. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRTB_MYCBO
AccessionPrimary (citable) accession number: P65861
Secondary accession number(s): Q50728
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways