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P65861

- CRTB_MYCBO

UniProt

P65861 - CRTB_MYCBO

Protein

Phytoene synthase

Gene

crtB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene Probable.Curated

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phytoene synthase (EC:2.5.1.-)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    Synonyms:phyA
    Ordered Locus Names:Mb3430c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Phytoene synthasePRO_0000067432Add
    BLAST

    Proteomic databases

    PRIDEiP65861.

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb3430c.

    Structurei

    3D structure databases

    ProteinModelPortaliP65861.
    SMRiP65861. Positions 1-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG1562.
    HOGENOMiHOG000220849.
    KOiK02291.
    OMAiICAPDEP.
    OrthoDBiEOG63FW00.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR017828. Squalene/phytoene_synth.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03465. HpnD. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65861-1 [UniParc]FASTAAdd to Basket

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    MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV    50
    ADGELAPETK ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA 100
    ELIDGARMEI DWTGCRDFDE LIVYCRRGAG TIGKLCLSIF GPVSTATSRY 150
    AEQLGIALQQ TNILRDVRED FLNGRIYLPR DELDRLGVRL RLDDTGALDD 200
    PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA MSGIYRRQLA 250
    LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP 300
    SH 302
    Length:302
    Mass (Da):33,142
    Last modified:October 11, 2004 - v1
    Checksum:iC214605A7B93AFFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44702.1.
    RefSeqiNP_857071.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD95618; CAD95618; Mb3430c.
    GeneIDi1090989.
    KEGGimbo:Mb3430c.
    PATRICi18009274. VBIMycBov88188_3765.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44702.1 .
    RefSeqi NP_857071.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P65861.
    SMRi P65861. Positions 1-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3430c.

    Proteomic databases

    PRIDEi P65861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD95618 ; CAD95618 ; Mb3430c .
    GeneIDi 1090989.
    KEGGi mbo:Mb3430c.
    PATRICi 18009274. VBIMycBov88188_3765.

    Phylogenomic databases

    eggNOGi COG1562.
    HOGENOMi HOG000220849.
    KOi K02291.
    OMAi ICAPDEP.
    OrthoDBi EOG63FW00.

    Enzyme and pathway databases

    UniPathwayi UPA00799 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR017828. Squalene/phytoene_synth.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03465. HpnD. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiCRTB_MYCBO
    AccessioniPrimary (citable) accession number: P65861
    Secondary accession number(s): Q50728, X2BN51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3