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P65860 (CRTB_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable phytoene synthase
EC=2.5.1.32
Gene names
Name:crtB
Synonyms:phyA
Ordered Locus Names:Rv3397c, MT3505
ORF Names:MTCY78.31
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reaction from prephytoene diphosphate to phytoene.

Catalytic activity

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Ontologies

Keywords
   Biological processCarotenoid biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Multifunctional enzyme
Reference proteome
Gene Ontology (GO)
   Biological_processcarotenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiongeranylgeranyl-diphosphate geranylgeranyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Probable phytoene synthase
PRO_0000067431

Sequences

Sequence LengthMass (Da)Tools
P65860 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C214605A7B93AFFD

FASTA30233,142
        10         20         30         40         50         60 
MTEIEQAYRI TESITRTAAR NFYYGIRLLP REKRAALSAV YALGRRIDDV ADGELAPETK 

        70         80         90        100        110        120 
ITELDAIRKS LDNIDDSSDP VLVALADAAR RFPVPIAMFA ELIDGARMEI DWTGCRDFDE 

       130        140        150        160        170        180 
LIVYCRRGAG TIGKLCLSIF GPVSTATSRY AEQLGIALQQ TNILRDVRED FLNGRIYLPR 

       190        200        210        220        230        240 
DELDRLGVRL RLDDTGALDD PDGRLAALLR FSADRAADWY SLGLRLIPHL DRRSAACCAA 

       250        260        270        280        290        300 
MSGIYRRQLA LIRASPAVVY DRRISLSGLK KAQVAAAALA SSVTCGPAHG PLPADLGSHP 


SH

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAB01026.1.
AE000516 Genomic DNA. Translation: AAK47842.1.
AL123456 Genomic DNA. Translation: CCP46219.1.
PIRB70735.
RefSeqNP_217914.1. NC_000962.3.
NP_338028.1. NC_002755.2.
YP_006516882.1. NC_018143.1.

3D structure databases

ProteinModelPortalP65860.
SMRP65860. Positions 1-260.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv3397c.

Proteomic databases

PRIDEP65860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK47842; AAK47842; MT3505.
GeneID13317000.
887911.
926583.
KEGGmtc:MT3505.
mtu:Rv3397c.
mtv:RVBD_3397c.
PATRIC18129449. VBIMycTub22151_3820.

Organism-specific databases

TubercuListRv3397c.

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000220849.
KOK02291.
OMAEWVEAFL.
ProtClustDBCLSK872176.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR017828. Squalene/phytoene_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
TIGRFAMsTIGR03465. HpnD. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRTB_MYCTU
AccessionPrimary (citable) accession number: P65860
Secondary accession number(s): L0TCN1, Q50728
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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