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P65828

- HPRT_STAAW

UniProt

P65828 - HPRT_STAAW

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Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021Proton acceptorBy similarity
Binding sitei130 – 1301IMPBy similarity
Binding sitei152 – 1521IMP; via carbonyl oxygenBy similarity
Metal bindingi158 – 1581MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi98 – 10710IMPBy similarity
Nucleotide bindingi157 – 1582IMPBy similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-470-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:MW0465
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Hypoxanthine-guanine phosphoribosyltransferasePRO_0000139617Add
BLAST

Proteomic databases

PRIDEiP65828.

Interactioni

Protein-protein interaction databases

STRINGi196620.MW0465.

Structurei

3D structure databases

ProteinModelPortaliP65828.
SMRiP65828. Positions 4-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0634.
HOGENOMiHOG000236520.
KOiK00760.
OMAiRGMEPDF.
OrthoDBiEOG693GNP.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

P65828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNDLKEVLL TEEDIQNICK ELGAQLTKDY QGKPLVCVGI LKGSAMFMSD
60 70 80 90 100
LIKRIDTHLS IDFMDVSSYH GGTESTGEVQ IIKDLGSSIE NKDVLIIEDI
110 120 130 140 150
LETGTTLKSI TELLQSRKVN SLEIVTLLDK PNRRKADIEA KYVGKKIPDE
160 170
FVVGYGLDYR ELYRNLPYIG TLKPEVYSN
Length:179
Mass (Da):20,154
Last modified:October 11, 2004 - v1
Checksum:iE7D35987B435EFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94330.1.
RefSeqiNP_645282.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94330; BAB94330; BAB94330.
GeneIDi1002569.
KEGGisam:MW0465.
PATRICi19567430. VBIStaAur44266_0493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94330.1 .
RefSeqi NP_645282.1. NC_003923.1.

3D structure databases

ProteinModelPortali P65828.
SMRi P65828. Positions 4-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW0465.

Proteomic databases

PRIDEi P65828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB94330 ; BAB94330 ; BAB94330 .
GeneIDi 1002569.
KEGGi sam:MW0465.
PATRICi 19567430. VBIStaAur44266_0493.

Phylogenomic databases

eggNOGi COG0634.
HOGENOMi HOG000236520.
KOi K00760.
OMAi RGMEPDF.
OrthoDBi EOG693GNP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci SAUR196620:GJ9Z-470-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiHPRT_STAAW
AccessioniPrimary (citable) accession number: P65828
Secondary accession number(s): Q99W93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3