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P65805

- PEPT_STAAM

UniProt

P65805 - PEPT_STAAM

Protein

Peptidase T

Gene

pepT

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi140 – 1401Zinc 1UniRule annotation
    Metal bindingi140 – 1401Zinc 2UniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Metal bindingi175 – 1751Zinc 2UniRule annotation
    Metal bindingi197 – 1971Zinc 1UniRule annotation
    Metal bindingi379 – 3791Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-760-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:SAV0743
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Peptidase TPRO_0000185316Add
    BLAST

    2D gel databases

    World-2DPAGE0002:P65805.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV0743.

    Structurei

    3D structure databases

    ProteinModelPortaliP65805.
    SMRiP65805. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiDCYIEVT.
    OrthoDBiEOG6SV59Q.
    PhylomeDBiP65805.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65805-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNQLIDRLT RYTTIDTQSD PKSTTTPSTE KQWDLLHLLE KELQQLGLPT    50
    DLDENGYLFA TLESNIDADV PTVGFLAHVD TSPDFNASNV KPQIIENYDG 100
    KPYKLGNTKR VLDPKVFPEL NSLVGHTLMV TDGTSLLGAD DKAGIVEIME 150
    AICYLQEHPE IKHGTIRIGF TPDEEIGRGP HKFDVDRFNA DFAYTMDGSQ 200
    YGELQYESFN AAEAVITCHG VNVHPGSAKN AMVNAIRLGE QFDSLLPDSE 250
    VPERTEGYEG FYHLMNFEGT VEKATLQYII RDHDKKQFEL RKKRILEIRD 300
    DINAHFENYP VKVDISDQYF NMAEKILPLP HIIDIPKRVF AKLDIPANTE 350
    PIRGGTDGSQ LSFMGLPTPN IFTGCGNFHG PYEYASIDVM EKAVQVIIGI 400
    VEDIAENH 408
    Length:408
    Mass (Da):45,820
    Last modified:October 11, 2004 - v1
    Checksum:i28A88DC436056671
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56905.1.
    RefSeqiNP_371267.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB56905; BAB56905; SAV0743.
    GeneIDi1120716.
    KEGGisav:SAV0743.
    PATRICi19562158. VBIStaAur52173_0760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56905.1 .
    RefSeqi NP_371267.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali P65805.
    SMRi P65805. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV0743.

    2D gel databases

    World-2DPAGE 0002:P65805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB56905 ; BAB56905 ; SAV0743 .
    GeneIDi 1120716.
    KEGGi sav:SAV0743.
    PATRICi 19562158. VBIStaAur52173_0760.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi DCYIEVT.
    OrthoDBi EOG6SV59Q.
    PhylomeDBi P65805.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-760-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiPEPT_STAAM
    AccessioniPrimary (citable) accession number: P65805
    Secondary accession number(s): Q99VN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3