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P65788 (PROA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:Rv2427c, MT2500
ORF Names:MTCY428.20
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000189753

Sequences

Sequence LengthMass (Da)Tools
P65788 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 071C9872F8C9A8AC

FASTA41543,745
        10         20         30         40         50         60 
MTVPAPSQLD LRQEVHDAAR RARVAARRLA SLPTTVKDRA LHAAADELLA HRDQILAANA 

        70         80         90        100        110        120 
EDLNAAREAD TPAAMLDRLS LNPQRVDGIA AGLRQVAGLR DPVGEVLRGY TLPNGLQLRQ 

       130        140        150        160        170        180 
QRVPLGVVGM IYEGRPNVTV DAFGLTLKSG NAALLRGSSS AAKSNEALVA VLRTALVGLE 

       190        200        210        220        230        240 
LPADAVQLLS AADRATVTHL IQARGLVDVV IPRGGAGLIE AVVRDAQVPT IETGVGNCHV 

       250        260        270        280        290        300 
YVHQAADLDV AERILLNSKT RRPSVCNAAE TLLVDAAIAE TALPRLLAAL QHAGVTVHLD 

       310        320        330        340        350        360 
PDEADLRREY LSLDIAVAVV DGVDAAIAHI NEYGTGHTEA IVTTNLDAAQ RFTEQIDAAA 

       370        380        390        400        410 
VMVNASTAFT DGEQFGFGAE IGISTQKLHA RGPMGLPELT STKWIAWGAG HTRPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAB03769.1.
AE000516 Genomic DNA. Translation: AAK46797.1.
PIRA70679.
RefSeqNP_216943.1. NC_000962.2.
NP_336983.1. NC_002755.2.

3D structure databases

ProteinModelPortalP65788.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002819; EBMYCP00000002819; EBMYCG00000002817.
EBMYCT00000069611; EBMYCP00000067670; EBMYCG00000069606.
GeneID885536.
925836.
GenomeReviewsGene locus MT2500 in contig AE000516_GR.
Gene locus Rv2427c in contig AL123456_GR.
KEGGmtc:MT2500.
mtu:Rv2427c.
PATRIC18127248. VBIMycTub22151_2732.
TIGRMT2500.

Organism-specific databases

TubercuListRv2427c.

Phylogenomic databases

GeneTreeEBGT00050000015663.
HOGENOMHBG318080.
OMAQYPAACN.
PhylomeDBP65788.
ProtClustDBPRK00197.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_MYCTU
AccessionPrimary (citable) accession number: P65788
Secondary accession number(s): P71921
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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