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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Proton acceptorUniRule annotation1
Binding sitei158NADUniRule annotation1
Binding sitei160NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 57NADUniRule annotation2
Nucleotide bindingi132 – 133NADUniRule annotation2
Nucleotide bindingi171 – 176NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SPy_1126, M5005_Spy0848
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206721 – 278NAD kinaseAdd BLAST278

Proteomic databases

PaxDbiP65781
PRIDEiP65781

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1126

Structurei

3D structure databases

ProteinModelPortaliP65781
SMRiP65781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

P65781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQMNYTGKV KRVAIIANGK YQSKRVASKL FSVFKDDPDF YLSKKNPDIV
60 70 80 90 100
ISIGGDGMLL SAFHMYEKEL DKVRFVGIHT GHLGFYTDYR DFEVDKLIDN
110 120 130 140 150
LRKDKGEQIS YPILKVAITL DDGRVVKARA LNEATVKRIE KTMVADVIIN
160 170 180 190 200
HVKFESFRGD GISVSTPTGS TAYNKSLGGA VLHPTIEALQ LTEISSLNNR
210 220 230 240 250
VFRTLGSSII IPKKDKIELV PKRLGIYTIS IDNKTYQLKN VTKVEYFIDD
260 270
EKIHFVSSPS HTSFWERVKD AFIGEIDS
Length:278
Mass (Da):31,376
Last modified:October 11, 2004 - v1
Checksum:iCB69C3C3527B4981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK34001.1
CP000017 Genomic DNA Translation: AAZ51466.1
RefSeqiNP_269280.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK34001; AAK34001; SPy_1126
AAZ51466; AAZ51466; M5005_Spy0848
GeneIDi901244
KEGGispy:SPy_1126
spz:M5005_Spy0848
PATRICifig|160490.10.peg.980

Similar proteinsi

Entry informationi

Entry nameiNADK_STRP1
AccessioniPrimary (citable) accession number: P65781
Secondary accession number(s): Q48YV6, Q99ZQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health