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P65779 (NADK_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:SP_1098
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein binding

Inferred from physical interaction PubMed 23267104. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SP_1473Q97PW73EBI-6472853,EBI-6472858

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272NAD kinase HAMAP-Rule MF_00361
PRO_0000120670

Regions

Nucleotide binding50 – 512NAD By similarity
Nucleotide binding126 – 1272NAD By similarity
Nucleotide binding165 – 1706NAD By similarity

Sites

Active site501Proton acceptor By similarity
Binding site1521NAD By similarity
Binding site1541NAD By similarity
Binding site1891NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P65779 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: B9C8FC6FE604B594

FASTA27231,035
        10         20         30         40         50         60 
MKNTGKRIDL IANRKPQSQR VLYELRDRLK RNQFILNDTN PDIVISIGGD GMLLSAFHKY 

        70         80         90        100        110        120 
ENQLDKVRFI GLHTGHLGFY TDYRDFELDK LVTNLQLDTG ARVSYPVLNV KVFLENGEVK 

       130        140        150        160        170        180 
IFRALNEASI RRSDRTMVAD IVINGVPFER FRGDGLTVST PTGSTAYNKS LGGAVLHPTI 

       190        200        210        220        230        240 
EALQLTEIAS LNNRVYRTLG SSIIVPKKDK IELIPTRNDY HTISVDNSVY SFRNIERIEY 

       250        260        270 
QIDHHKIHFV ATPSHTSFWN RVKDAFIGEV DE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK75210.1.
PIRA95127.
RefSeqNP_345570.1. NC_003028.3.

3D structure databases

ProteinModelPortalP65779.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP65779. 1 interaction.
STRING170187.SP_1098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75210; AAK75210; SP_1098.
GeneID931612.
KEGGspn:SP_1098.
PATRIC19706603. VBIStrPne105772_1146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAIQMSEIA.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-1103-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_STRPN
AccessionPrimary (citable) accession number: P65779
Secondary accession number(s): Q97QV0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families