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P65779

- NADK_STRPN

UniProt

P65779 - NADK_STRPN

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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton acceptorUniRule annotation
Binding sitei152 – 1521NADUniRule annotation
Binding sitei154 – 1541NADUniRule annotation
Binding sitei189 – 1891NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 512NADUniRule annotation
Nucleotide bindingi126 – 1272NADUniRule annotation
Nucleotide bindingi165 – 1706NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SP_1098
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272NAD kinasePRO_0000120670Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP_1473Q97PW73EBI-6472853,EBI-6472858

Protein-protein interaction databases

IntActiP65779. 1 interaction.
STRINGi170187.SP_1098.

Structurei

3D structure databases

ProteinModelPortaliP65779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiIQMSEIA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P65779-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNTGKRIDL IANRKPQSQR VLYELRDRLK RNQFILNDTN PDIVISIGGD
60 70 80 90 100
GMLLSAFHKY ENQLDKVRFI GLHTGHLGFY TDYRDFELDK LVTNLQLDTG
110 120 130 140 150
ARVSYPVLNV KVFLENGEVK IFRALNEASI RRSDRTMVAD IVINGVPFER
160 170 180 190 200
FRGDGLTVST PTGSTAYNKS LGGAVLHPTI EALQLTEIAS LNNRVYRTLG
210 220 230 240 250
SSIIVPKKDK IELIPTRNDY HTISVDNSVY SFRNIERIEY QIDHHKIHFV
260 270
ATPSHTSFWN RVKDAFIGEV DE
Length:272
Mass (Da):31,035
Last modified:October 11, 2004 - v1
Checksum:iB9C8FC6FE604B594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75210.1.
PIRiA95127.
RefSeqiNP_345570.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75210; AAK75210; SP_1098.
GeneIDi931612.
KEGGispn:SP_1098.
PATRICi19706603. VBIStrPne105772_1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75210.1 .
PIRi A95127.
RefSeqi NP_345570.1. NC_003028.3.

3D structure databases

ProteinModelPortali P65779.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P65779. 1 interaction.
STRINGi 170187.SP_1098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75210 ; AAK75210 ; SP_1098 .
GeneIDi 931612.
KEGGi spn:SP_1098.
PATRICi 19706603. VBIStrPne105772_1146.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi IQMSEIA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1103-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiNADK_STRPN
AccessioniPrimary (citable) accession number: P65779
Secondary accession number(s): Q97QV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3