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P65771

- NADK2_LISIN

UniProt

P65771 - NADK2_LISIN

Protein

NAD kinase 2

Gene

nadK2

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton acceptorUniRule annotation
    Binding sitei55 – 551NADUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei186 – 1861NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 512NADUniRule annotation
    Nucleotide bindingi122 – 1232NADUniRule annotation
    Nucleotide bindingi162 – 1676NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:lin1628
    OrganismiListeria innocua serovar 6a (strain CLIP 11262)
    Taxonomic identifieri272626 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002513: Chromosome

    Organism-specific databases

    GenoListiLIN1628.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267NAD kinase 2PRO_0000120629Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272626.lin1628.

    Structurei

    3D structure databases

    ProteinModelPortaliP65771.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiDDLHFET.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P65771-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTIFYFSY RKTEELHAKA KELKKITTDY GYELTDDYQK ANVIISIGGD    50
    GAFLKSVRET GFRQDCLYAG IALTEQLGQY CDFHINQLDE IIKAAIEDRW 100
    LVRRYPTIYG TVNNTKAFYV LNEFNIRSSI IRTLTMDLYI NDSHFETFRG 150
    DGMVISTPTG STAYNKSVNG SIVDPLLPSM QVSELASINN NKFRTLGSSF 200
    ILSPKRKLRI EIASEEGNNE FPMIGMDSEA LSIQHVHEVN LEVGDRFINI 250
    IKLPKNSFWD KVKRNFL 267
    Length:267
    Mass (Da):30,499
    Last modified:October 11, 2004 - v1
    Checksum:i69512B6100D49F73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596169 Genomic DNA. Translation: CAC96859.1.
    PIRiAC1636.
    RefSeqiNP_470964.1. NC_003212.1.

    Genome annotation databases

    EnsemblBacteriaiCAC96859; CAC96859; CAC96859.
    GeneIDi1130251.
    KEGGilin:lin1628.
    PATRICi20299993. VBILisInn102668_1663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596169 Genomic DNA. Translation: CAC96859.1 .
    PIRi AC1636.
    RefSeqi NP_470964.1. NC_003212.1.

    3D structure databases

    ProteinModelPortali P65771.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272626.lin1628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC96859 ; CAC96859 ; CAC96859 .
    GeneIDi 1130251.
    KEGGi lin:lin1628.
    PATRICi 20299993. VBILisInn102668_1663.

    Organism-specific databases

    GenoListi LIN1628.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi DDLHFET.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP 11262.

    Entry informationi

    Entry nameiNADK2_LISIN
    AccessioniPrimary (citable) accession number: P65771
    Secondary accession number(s): Q92BC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3