nadK2

Functionⁱ

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityⁱ

ATP + NAD⁺ = ADP + NADP⁺.UniRule annotation

Cofactorⁱ

a divalent metal cationUniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	50	Proton acceptorUniRule annotation	1
Binding siteⁱ	55	NADUniRule annotation	1
Binding siteⁱ	149	NADUniRule annotation	1
Binding siteⁱ	151	NADUniRule annotation	1
Binding siteⁱ	186	NAD; via carbonyl oxygenUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	50 – 51	NADUniRule annotation	2
Nucleotide bindingⁱ	122 – 123	NADUniRule annotation	2
Nucleotide bindingⁱ	162 – 167	NADUniRule annotation	6

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
NAD+ kinase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

NAD metabolic process Source: InterPro
NADP biosynthetic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation) Alternative name(s): ATP-dependent NAD kinase 2UniRule annotation
Gene namesⁱ	Name:nadK2UniRule annotation Ordered Locus Names:lmo1586
Organismⁱ	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifierⁱ	169963 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes
Proteomesⁱ	UP000000817 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00361

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000120633	1 – 267	NAD kinase 2Add BLAST		267

Proteomic databases

PaxDbⁱ	P65770.

PaxDbⁱ

P65770.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	169963.lmo1586.

STRINGⁱ

169963.lmo1586.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P65770.
SMRⁱ	P65770.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108KKH. Bacteria. COG0061. LUCA.
HOGENOMⁱ	HOG000275803.
KEGG Orthology (KO) More...KOⁱ	K00858.
OMAⁱ	EVRKYPL.
PhylomeDBⁱ	P65770.

Family and domain databases

Gene3Dⁱ	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAPⁱ	MF_00361. NAD_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR017438. ATP-NAD_kinase_dom_1. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR016064. NAD/diacylglycerol_kinase. IPR002504. NADK.
PANTHERⁱ	PTHR20275. PTHR20275. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01513. NAD_kinase. 1 hit.
SUPFAMⁱ	SSF111331. SSF111331. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P65770-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKTIFYFSY RKTEELHAKA KELKKITTDY GYELTDDYQK ANVIISIGGD 
        60         70         80         90        100
GAFLKSVRET GFRQDCLYAG IALTEQLGQY CDFHINQLDE IIKAAIEDRW 
       110        120        130        140        150
LVRRYPTIYG TVNNTKAFYV LNEFNIRSSI IRTLTMDLYI NDSHFETFRG 
       160        170        180        190        200
DGMVISTPTG STAYNKSVNG SIVDPLLPSM QVSELASINN NKFRTLGSSF 
       210        220        230        240        250
ILSPKRKLRI EIASEEGNNE FPMIGMDSEA LSIQHVHEVN LEVGDRFINI 
       260 
IKLPKNSFWD KVKRNFL

Length:267

Mass (Da):30,499

Last modified:October 11, 2004 - v1

Checksum:ⁱ69512B6100D49F73

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL591979 Genomic DNA. Translation: CAC99664.1.
PIRⁱ	AB1273.
NCBI Reference Sequences More...RefSeqⁱ	NP_465111.1. NC_003210.1. WP_003723315.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAC99664; CAC99664; CAC99664.
GeneIDⁱ	987765.
KEGGⁱ	lmo:lmo1586.
PATRICⁱ	fig\|169963.11.peg.1628.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL591979 Genomic DNA. Translation: CAC99664.1.
PIRⁱ	AB1273.
NCBI Reference Sequences More...RefSeqⁱ	NP_465111.1. NC_003210.1. WP_003723315.1. NC_003210.1.

3D structure databases

ProteinModelPortalⁱ	P65770.
SMRⁱ	P65770.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	169963.lmo1586.

STRINGⁱ

169963.lmo1586.

Proteomic databases

PaxDbⁱ	P65770.

PaxDbⁱ

P65770.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAC99664; CAC99664; CAC99664.
GeneIDⁱ	987765.
KEGGⁱ	lmo:lmo1586.
PATRICⁱ	fig\|169963.11.peg.1628.

Phylogenomic databases

eggNOGⁱ	ENOG4108KKH. Bacteria. COG0061. LUCA.
HOGENOMⁱ	HOG000275803.
KEGG Orthology (KO) More...KOⁱ	K00858.
OMAⁱ	EVRKYPL.
PhylomeDBⁱ	P65770.

Family and domain databases

Gene3Dⁱ	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAPⁱ	MF_00361. NAD_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR017438. ATP-NAD_kinase_dom_1. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR016064. NAD/diacylglycerol_kinase. IPR002504. NADK.
PANTHERⁱ	PTHR20275. PTHR20275. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01513. NAD_kinase. 1 hit.
SUPFAMⁱ	SSF111331. SSF111331. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NADK2_LISMO
Accessionⁱ	P65770Primary (citable) accession number: P65770 Secondary accession number(s): Q92BC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	October 11, 2004
	Last modified:	June 7, 2017
	This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P65770 (NADK2_LISMO)

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NAD kinase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ