UniProtKB - P65770 (NADK2_LISMO)
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Protein
NAD kinase 2
Gene
nadK2
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Functioni
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation
Catalytic activityi
ATP + NAD+ = ADP + NADP+.UniRule annotation
Cofactori
a divalent metal cationUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 50 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 55 | NADUniRule annotation | 1 | |
Binding sitei | 149 | NADUniRule annotation | 1 | |
Binding sitei | 151 | NADUniRule annotation | 1 | |
Binding sitei | 186 | NAD; via carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 50 – 51 | NADUniRule annotation | 2 | |
Nucleotide bindingi | 122 – 123 | NADUniRule annotation | 2 | |
Nucleotide bindingi | 162 – 167 | NADUniRule annotation | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- NAD+ kinase activity Source: UniProtKB-EC
GO - Biological processi
- NAD metabolic process Source: InterPro
- NADP biosynthetic process Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, NAD, NADP, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | LMON169963:G1GTA-1674-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)Alternative name(s): ATP-dependent NAD kinase 2UniRule annotation |
Gene namesi | Name:nadK2UniRule annotation Ordered Locus Names:lmo1586 |
Organismi | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) |
Taxonomic identifieri | 169963 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120633 | 1 – 267 | NAD kinase 2Add BLAST | 267 |
Proteomic databases
PaxDbi | P65770. |
Structurei
3D structure databases
ProteinModelPortali | P65770. |
SMRi | P65770. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the NAD kinase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108KKH. Bacteria. COG0061. LUCA. |
HOGENOMi | HOG000275803. |
KOi | K00858. |
OMAi | EVRKYPL. |
PhylomeDBi | P65770. |
Family and domain databases
Gene3Di | 2.60.200.30. 1 hit. 3.40.50.10330. 2 hits. |
HAMAPi | MF_00361. NAD_kinase. 1 hit. |
InterProi | View protein in InterPro IPR017438. ATP-NAD_kinase_N. IPR017437. ATP-NAD_kinase_PpnK-typ_C. IPR016064. NAD/diacylglycerol_kinase_sf. IPR002504. NADK. |
PANTHERi | PTHR20275. PTHR20275. 1 hit. |
Pfami | View protein in Pfam PF01513. NAD_kinase. 1 hit. |
SUPFAMi | SSF111331. SSF111331. 1 hit. |
i Sequence
Sequence statusi: Complete.
P65770-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKTIFYFSY RKTEELHAKA KELKKITTDY GYELTDDYQK ANVIISIGGD
60 70 80 90 100
GAFLKSVRET GFRQDCLYAG IALTEQLGQY CDFHINQLDE IIKAAIEDRW
110 120 130 140 150
LVRRYPTIYG TVNNTKAFYV LNEFNIRSSI IRTLTMDLYI NDSHFETFRG
160 170 180 190 200
DGMVISTPTG STAYNKSVNG SIVDPLLPSM QVSELASINN NKFRTLGSSF
210 220 230 240 250
ILSPKRKLRI EIASEEGNNE FPMIGMDSEA LSIQHVHEVN LEVGDRFINI
260
IKLPKNSFWD KVKRNFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591979 Genomic DNA. Translation: CAC99664.1. |
PIRi | AB1273. |
RefSeqi | NP_465111.1. NC_003210.1. WP_003723315.1. NC_003210.1. |
Genome annotation databases
EnsemblBacteriai | CAC99664; CAC99664; CAC99664. |
GeneIDi | 987765. |
KEGGi | lmo:lmo1586. |
PATRICi | fig|169963.11.peg.1628. |
Similar proteinsi
Entry informationi
Entry namei | NADK2_LISMO | |
Accessioni | P65770Primary (citable) accession number: P65770 Secondary accession number(s): Q92BC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 28, 2018 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |