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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:SAV1919
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585801 – 309Probable manganese-dependent inorganic pyrophosphataseAdd BLAST309

Proteomic databases

PaxDbiP65752.
PRIDEiP65752.

2D gel databases

World-2DPAGE0002:P65752.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1919.

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi14 – 29Combined sources16
Beta strandi35 – 41Combined sources7
Helixi45 – 53Combined sources9
Beta strandi70 – 75Combined sources6
Helixi79 – 81Combined sources3
Helixi86 – 88Combined sources3
Beta strandi89 – 96Combined sources8
Beta strandi110 – 113Combined sources4
Beta strandi115 – 117Combined sources3
Helixi119 – 130Combined sources12
Helixi136 – 150Combined sources15
Turni151 – 154Combined sources4
Helixi160 – 173Combined sources14
Helixi177 – 187Combined sources11
Helixi196 – 201Combined sources6
Beta strandi204 – 209Combined sources6
Beta strandi212 – 223Combined sources12
Helixi224 – 228Combined sources5
Helixi231 – 245Combined sources15
Beta strandi248 – 256Combined sources9
Turni257 – 259Combined sources3
Beta strandi262 – 268Combined sources7
Helixi271 – 275Combined sources5
Beta strandi280 – 283Combined sources4
Beta strandi285 – 292Combined sources8
Beta strandi295 – 297Combined sources3
Helixi299 – 308Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RPAX-ray2.10A/B1-309[»]
ProteinModelPortaliP65752.
SMRiP65752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiP65752.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTYIFGHK NPDTDAISSA IIMAEFEQLR GNSGAKAYRL GDVSAETQFA
60 70 80 90 100
LDTFNVPAPE LLTDDLDGQD VILVDHNEFQ QSSDTIASAT IKHVIDHHRI
110 120 130 140 150
ANFETAGPLC YRAEPVGCTA TILYKMFRER GFEIKPEIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTQ QDVKAAEELK DIAKVDIQKY GLDMLKAGAS TTDKSVEFLL
210 220 230 240 250
NMDAKSFTMG DYVTRIAQVN AVDLDEVLNR KEDLEKEMLA VSAQEKYDLF
260 270 280 290 300
VLVVTDIINS DSKILVVGAE KDKVGEAFNV QLEDDMAFLS GVVSRKKQIV

PQITEALTK
Length:309
Mass (Da):34,069
Last modified:October 11, 2004 - v1
Checksum:i39EB877DA5E485A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58081.1.
RefSeqiWP_001140871.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58081; BAB58081; SAV1919.
GeneIDi28380432.
KEGGisav:SAV1919.
PATRICi19564694. VBIStaAur52173_1987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58081.1.
RefSeqiWP_001140871.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RPAX-ray2.10A/B1-309[»]
ProteinModelPortaliP65752.
SMRiP65752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1919.

2D gel databases

World-2DPAGE0002:P65752.

Proteomic databases

PaxDbiP65752.
PRIDEiP65752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58081; BAB58081; SAV1919.
GeneIDi28380432.
KEGGisav:SAV1919.
PATRICi19564694. VBIStaAur52173_1987.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiP65752.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STAAM
AccessioniPrimary (citable) accession number: P65752
Secondary accession number(s): Q99SW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.