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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Magnesium 1By similarity
Metal bindingi57 – 571Magnesium 1By similarity
Metal bindingi57 – 571Magnesium 2By similarity
Metal bindingi89 – 891Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:Mb3652
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Inorganic pyrophosphatasePRO_0000137513Add
BLAST

Interactioni

Chemistry

BindingDBiP65747.

Structurei

3D structure databases

ProteinModelPortaliP65747.
SMRiP65747. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

HOGENOMiHOG000236473.
KOiK01507.
OMAiPVALMKM.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDVTIEIP KGQRNKYEVD HETGRVRLDR YLYTPMAYPT DYGFIEDTLG
60 70 80 90 100
DDGDPLDALV LLPQPVFPGV LVAARPVGMF RMVDEHGGDD KVLCVPAGDP
110 120 130 140 150
RWDHVQDIGD VPAFELDAIK HFFVHYKDLE PGKFVKAADW VDRAEAEAEV
160
QRSVERFKAG TH
Length:162
Mass (Da):18,329
Last modified:October 11, 2004 - v1
Checksum:i4ED0B35ECC7D1961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44923.1.
RefSeqiNP_857291.1. NC_002945.3.
WP_003419577.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44923; CDO44923; Mb3652.
GeneIDi1093220.
KEGGimbo:Mb3652.
PATRICi18009739. VBIMycBov88188_3997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44923.1.
RefSeqiNP_857291.1. NC_002945.3.
WP_003419577.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP65747.
SMRiP65747. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP65747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44923; CDO44923; Mb3652.
GeneIDi1093220.
KEGGimbo:Mb3652.
PATRICi18009739. VBIMycBov88188_3997.

Phylogenomic databases

HOGENOMiHOG000236473.
KOiK01507.
OMAiPVALMKM.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiIPYR_MYCBO
AccessioniPrimary (citable) accession number: P65747
Secondary accession number(s): O06379, X2BP74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.