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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Magnesium 2UniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Binding sitei30SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Metal bindingi52Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 2UniRule annotation1
Metal bindingi84Magnesium 3UniRule annotation1
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi89Magnesium 1UniRule annotation1
Metal bindingi89Magnesium 3UniRule annotation1
Binding sitei126SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:Mb3652
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375131 – 162Inorganic pyrophosphataseAdd BLAST162

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP65747.
SMRiP65747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000236473.
KOiK01507.
OMAiAVYYPAN.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDVTIEIP KGQRNKYEVD HETGRVRLDR YLYTPMAYPT DYGFIEDTLG
60 70 80 90 100
DDGDPLDALV LLPQPVFPGV LVAARPVGMF RMVDEHGGDD KVLCVPAGDP
110 120 130 140 150
RWDHVQDIGD VPAFELDAIK HFFVHYKDLE PGKFVKAADW VDRAEAEAEV
160
QRSVERFKAG TH
Length:162
Mass (Da):18,329
Last modified:October 11, 2004 - v1
Checksum:i4ED0B35ECC7D1961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44923.1.
RefSeqiNP_857291.1. NC_002945.3.
WP_003419577.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44923; CDO44923; Mb3652.
GeneIDi1093220.
KEGGimbo:Mb3652.
PATRICi18009739. VBIMycBov88188_3997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44923.1.
RefSeqiNP_857291.1. NC_002945.3.
WP_003419577.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP65747.
SMRiP65747.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44923; CDO44923; Mb3652.
GeneIDi1093220.
KEGGimbo:Mb3652.
PATRICi18009739. VBIMycBov88188_3997.

Phylogenomic databases

HOGENOMiHOG000236473.
KOiK01507.
OMAiAVYYPAN.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_MYCBO
AccessioniPrimary (citable) accession number: P65747
Secondary accession number(s): O06379, X2BP74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.