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P65733

- PKNJ_MYCBO

UniProt

P65733 - PKNJ_MYCBO

Protein

Serine/threonine-protein kinase PknJ

Gene

pknJ

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPPROSITE-ProRule annotation
    Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknJ (EC:2.7.11.1)
    Gene namesi
    Name:pknJ
    Ordered Locus Names:Mb2115
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Serine/threonine-protein kinase PknJPRO_0000171221Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb2115.

    Structurei

    3D structure databases

    ProteinModelPortaliP65733.
    SMRiP65733. Positions 4-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 342342CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini364 – 589226ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 276263Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08884.
    OMAiARHTEDN.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR026954. PknH-like_Extracell.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF14032. PknH_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65733-1 [UniParc]FASTAAdd to Basket

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    MAHELSAGSV FAGYRIERML GAGGMGTVYL ARNPDLPRSE ALKVLAAELS    50
    RDLDFRARFV READVAAGLD HPNIVAVHQR GQFEGRLWIA MQFVDGGNAE 100
    DALRAATMTT ARAVYVIGEV AKALDYAHQQ GVIHRDIKPA NFLLSRAAGG 150
    DERVLLSDFG IARALGDTGL TSTGSVLATL AYAAPEVLAG QGFDGRADLY 200
    SLGCALFRLL TGEAPFAAGA GAAVAVVAGH LHQPPPTVSD RVPGLSAAMD 250
    AVIATAMAKD PMRRFTSAGE FAHAAAAALY GGATDGWVPP SPAPHVISQG 300
    AVPGSPWWQH PVGSVTALAT PPGHGWPPGL PPLPRRPRRY RRGVAAVAAV 350
    MVVAAAAVTA VTMTSHQPRT ATPPSAAALS PTSSSTTPPQ PPIVTRSRLP 400
    GLLPPLDDVK NFVGIQNLVA HEPMLQPQTP NGSINPAECW PAVGGGVPSA 450
    YDLGTVIGFY GLTIDEPPTG TAPNQVGQLI VAFRDAATAQ RHLADLASIW 500
    RRCGGRTVTL FRSEWRRPVE LSTSVPEVVD GITTMVLTAQ GPVLRVREDH 550
    AIAAKNNVLV DVDIMTPDTS RGQQAVIGIT NYILAKIPG 589
    Length:589
    Mass (Da):61,595
    Last modified:October 11, 2004 - v1
    Checksum:iE1E179150E2D348E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43368.1.
    RefSeqiNP_855764.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96968; CAD96968; Mb2115.
    GeneIDi1091131.
    KEGGimbo:Mb2115.
    PATRICi18006356. VBIMycBov88188_2325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43368.1 .
    RefSeqi NP_855764.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P65733.
    SMRi P65733. Positions 4-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96968 ; CAD96968 ; Mb2115 .
    GeneIDi 1091131.
    KEGGi mbo:Mb2115.
    PATRICi 18006356. VBIMycBov88188_2325.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08884.
    OMAi ARHTEDN.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR026954. PknH-like_Extracell.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF14032. PknH_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPKNJ_MYCBO
    AccessioniPrimary (citable) accession number: P65733
    Secondary accession number(s): Q10697, X2BK37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3