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Protein

Serine/threonine-protein kinase PknJ

Gene

pknJ

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknJ (EC:2.7.11.1)
Gene namesi
Name:pknJ
Ordered Locus Names:Mb2115
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 342342CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Topological domaini364 – 589226ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Serine/threonine-protein kinase PknJPRO_0000171221Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP65733.
SMRiP65733. Positions 4-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 276263Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
KOiK08884.
OMAiGADIFAW.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHELSAGSV FAGYRIERML GAGGMGTVYL ARNPDLPRSE ALKVLAAELS
60 70 80 90 100
RDLDFRARFV READVAAGLD HPNIVAVHQR GQFEGRLWIA MQFVDGGNAE
110 120 130 140 150
DALRAATMTT ARAVYVIGEV AKALDYAHQQ GVIHRDIKPA NFLLSRAAGG
160 170 180 190 200
DERVLLSDFG IARALGDTGL TSTGSVLATL AYAAPEVLAG QGFDGRADLY
210 220 230 240 250
SLGCALFRLL TGEAPFAAGA GAAVAVVAGH LHQPPPTVSD RVPGLSAAMD
260 270 280 290 300
AVIATAMAKD PMRRFTSAGE FAHAAAAALY GGATDGWVPP SPAPHVISQG
310 320 330 340 350
AVPGSPWWQH PVGSVTALAT PPGHGWPPGL PPLPRRPRRY RRGVAAVAAV
360 370 380 390 400
MVVAAAAVTA VTMTSHQPRT ATPPSAAALS PTSSSTTPPQ PPIVTRSRLP
410 420 430 440 450
GLLPPLDDVK NFVGIQNLVA HEPMLQPQTP NGSINPAECW PAVGGGVPSA
460 470 480 490 500
YDLGTVIGFY GLTIDEPPTG TAPNQVGQLI VAFRDAATAQ RHLADLASIW
510 520 530 540 550
RRCGGRTVTL FRSEWRRPVE LSTSVPEVVD GITTMVLTAQ GPVLRVREDH
560 570 580
AIAAKNNVLV DVDIMTPDTS RGQQAVIGIT NYILAKIPG
Length:589
Mass (Da):61,595
Last modified:October 11, 2004 - v1
Checksum:iE1E179150E2D348E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43368.1.
RefSeqiNP_855764.1. NC_002945.3.
WP_003410735.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43368; CDO43368; Mb2115.
GeneIDi1091131.
KEGGimbo:Mb2115.
PATRICi18006356. VBIMycBov88188_2325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43368.1.
RefSeqiNP_855764.1. NC_002945.3.
WP_003410735.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP65733.
SMRiP65733. Positions 4-340.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43368; CDO43368; Mb2115.
GeneIDi1091131.
KEGGimbo:Mb2115.
PATRICi18006356. VBIMycBov88188_2325.

Phylogenomic databases

eggNOGiCOG0515.
KOiK08884.
OMAiGADIFAW.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026954. PknH-like_Extracell.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14032. PknH_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNJ_MYCBO
AccessioniPrimary (citable) accession number: P65733
Secondary accession number(s): Q10697, X2BK37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.