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Protein

Serine/threonine-protein kinase PknI

Gene

pknI

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in slowing down the growth of mycobacteria within the infected host.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATPPROSITE-ProRule annotation
Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknI (EC:2.7.11.1)
Gene namesi
Name:pknI
Ordered Locus Names:Mb2938c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 349349CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Topological domaini371 – 585215ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Serine/threonine-protein kinase PknIPRO_0000171219Add
BLAST

Post-translational modificationi

Autophosphorylated at serine and threonine residues.By similarity

Structurei

3D structure databases

ProteinModelPortaliP65731.
SMRiP65731. Positions 12-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 252241Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000047111.
KOiK08884.
OMAiWAFRSAC.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALASGVTFA GYTVVRMLGC SAMGEVYLVQ HPGFPGWQAL KVLSPAMAAD
60 70 80 90 100
DEFRRRFQRE TEVAARLFHP HILEVHDRGE FDGQLWIAMD YVDGIDATQH
110 120 130 140 150
MADRFPAVLP VGEVLAIVTA VAGALDYAHQ RGLLHRDVNP ANVVLTSQSA
160 170 180 190 200
GDQRILLADF GIASQPSYPA PELSAGADVD GRADQYALAL TAIHLFAGAP
210 220 230 240 250
PVDRSHTGPL QPPKLSAFRP DLARLDGVLS RALATAPADR FGSCREFADA
260 270 280 290 300
MNEQAGVAIA DQSSGGVDAS EVTAAAGEEA YVVDYPAYGW PEAVDCKEPS
310 320 330 340 350
ARAPAPAAPT PQRRGSMLQS AAGVLARRLD NFSTATKAPA SPTRRRPRRI
360 370 380 390 400
LVGAVAVLLL AGLFAVGIVI GRKTNTTATE VARPPTSGSA VPSAPTTTVA
410 420 430 440 450
VTAPVPLDGT YRIEIQRSKQ TYDYTPTPQP PDVNTWWAFR TSCTPTECLA
460 470 480 490 500
AATMLDDNDH TQAKTPPVRP FLMQFGEGQW KSRPETVQFP CVGPNGSPST
510 520 530 540 550
QATTQLLALR PQPQGDLVGE MVVTVHSNEC GQQGAVIRIP AVASRSGDLP
560 570 580
PAVTVPDPAT IPDTPDTTST ATLTPPTTTA PGPGR
Length:585
Mass (Da):61,805
Last modified:October 11, 2004 - v1
Checksum:iE52EACFF4A69C3EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1.
RefSeqiNP_856583.1. NC_002945.3.
WP_003900593.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44205; CDO44205; Mb2938c.
GeneIDi1092167.
KEGGimbo:Mb2938c.
PATRICi18008184. VBIMycBov88188_3224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1.
RefSeqiNP_856583.1. NC_002945.3.
WP_003900593.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP65731.
SMRiP65731. Positions 12-246.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44205; CDO44205; Mb2938c.
GeneIDi1092167.
KEGGimbo:Mb2938c.
PATRICi18008184. VBIMycBov88188_3224.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000047111.
KOiK08884.
OMAiWAFRSAC.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNI_MYCBO
AccessioniPrimary (citable) accession number: P65731
Secondary accession number(s): Q10964, X2BMF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.