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P65731

- PKNI_MYCBO

UniProt

P65731 - PKNI_MYCBO

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Protein

Serine/threonine-protein kinase PknI

Gene

pknI

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays an important role in slowing down the growth of mycobacteria within the infected host.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATPPROSITE-ProRule annotation
Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknI (EC:2.7.11.1)
Gene namesi
Name:pknI
Ordered Locus Names:Mb2938c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Single-pass membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Serine/threonine-protein kinase PknIPRO_0000171219Add
BLAST

Post-translational modificationi

Autophosphorylated at serine and threonine residues.By similarity

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2938c.

Structurei

3D structure databases

ProteinModelPortaliP65731.
SMRiP65731. Positions 12-246.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 349349CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini371 – 585215ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 252241Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000047111.
KOiK08884.
OMAiNILLTHP.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALASGVTFA GYTVVRMLGC SAMGEVYLVQ HPGFPGWQAL KVLSPAMAAD
60 70 80 90 100
DEFRRRFQRE TEVAARLFHP HILEVHDRGE FDGQLWIAMD YVDGIDATQH
110 120 130 140 150
MADRFPAVLP VGEVLAIVTA VAGALDYAHQ RGLLHRDVNP ANVVLTSQSA
160 170 180 190 200
GDQRILLADF GIASQPSYPA PELSAGADVD GRADQYALAL TAIHLFAGAP
210 220 230 240 250
PVDRSHTGPL QPPKLSAFRP DLARLDGVLS RALATAPADR FGSCREFADA
260 270 280 290 300
MNEQAGVAIA DQSSGGVDAS EVTAAAGEEA YVVDYPAYGW PEAVDCKEPS
310 320 330 340 350
ARAPAPAAPT PQRRGSMLQS AAGVLARRLD NFSTATKAPA SPTRRRPRRI
360 370 380 390 400
LVGAVAVLLL AGLFAVGIVI GRKTNTTATE VARPPTSGSA VPSAPTTTVA
410 420 430 440 450
VTAPVPLDGT YRIEIQRSKQ TYDYTPTPQP PDVNTWWAFR TSCTPTECLA
460 470 480 490 500
AATMLDDNDH TQAKTPPVRP FLMQFGEGQW KSRPETVQFP CVGPNGSPST
510 520 530 540 550
QATTQLLALR PQPQGDLVGE MVVTVHSNEC GQQGAVIRIP AVASRSGDLP
560 570 580
PAVTVPDPAT IPDTPDTTST ATLTPPTTTA PGPGR
Length:585
Mass (Da):61,805
Last modified:October 11, 2004 - v1
Checksum:iE52EACFF4A69C3EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1.
RefSeqiNP_856583.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96625; CAD96625; Mb2938c.
GeneIDi1092167.
KEGGimbo:Mb2938c.
PATRICi18008184. VBIMycBov88188_3224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1 .
RefSeqi NP_856583.1. NC_002945.3.

3D structure databases

ProteinModelPortali P65731.
SMRi P65731. Positions 12-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2938c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96625 ; CAD96625 ; Mb2938c .
GeneIDi 1092167.
KEGGi mbo:Mb2938c.
PATRICi 18008184. VBIMycBov88188_3224.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000047111.
KOi K08884.
OMAi NILLTHP.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNI_MYCBO
AccessioniPrimary (citable) accession number: P65731
Secondary accession number(s): Q10964, X2BMF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3