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P65731

- PKNI_MYCBO

UniProt

P65731 - PKNI_MYCBO

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Protein
Serine/threonine-protein kinase PknI
Gene
pknI, Mb2938c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays an important role in slowing down the growth of mycobacteria within the infected host By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP By similarity
Active sitei137 – 1371Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknI (EC:2.7.11.1)
Gene namesi
Name:pknI
Ordered Locus Names:Mb2938c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 349349Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei350 – 37021Helical; Reviewed prediction
Add
BLAST
Topological domaini371 – 585215Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Serine/threonine-protein kinase PknI
PRO_0000171219Add
BLAST

Post-translational modificationi

Autophosphorylated at serine and threonine residues By similarity.

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2938c.

Structurei

3D structure databases

ProteinModelPortaliP65731.
SMRiP65731. Positions 12-246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 252241Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000047111.
KOiK08884.
OMAiNILLTHP.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65731-1 [UniParc]FASTAAdd to Basket

« Hide

MALASGVTFA GYTVVRMLGC SAMGEVYLVQ HPGFPGWQAL KVLSPAMAAD    50
DEFRRRFQRE TEVAARLFHP HILEVHDRGE FDGQLWIAMD YVDGIDATQH 100
MADRFPAVLP VGEVLAIVTA VAGALDYAHQ RGLLHRDVNP ANVVLTSQSA 150
GDQRILLADF GIASQPSYPA PELSAGADVD GRADQYALAL TAIHLFAGAP 200
PVDRSHTGPL QPPKLSAFRP DLARLDGVLS RALATAPADR FGSCREFADA 250
MNEQAGVAIA DQSSGGVDAS EVTAAAGEEA YVVDYPAYGW PEAVDCKEPS 300
ARAPAPAAPT PQRRGSMLQS AAGVLARRLD NFSTATKAPA SPTRRRPRRI 350
LVGAVAVLLL AGLFAVGIVI GRKTNTTATE VARPPTSGSA VPSAPTTTVA 400
VTAPVPLDGT YRIEIQRSKQ TYDYTPTPQP PDVNTWWAFR TSCTPTECLA 450
AATMLDDNDH TQAKTPPVRP FLMQFGEGQW KSRPETVQFP CVGPNGSPST 500
QATTQLLALR PQPQGDLVGE MVVTVHSNEC GQQGAVIRIP AVASRSGDLP 550
PAVTVPDPAT IPDTPDTTST ATLTPPTTTA PGPGR 585
Length:585
Mass (Da):61,805
Last modified:October 11, 2004 - v1
Checksum:iE52EACFF4A69C3EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1.
RefSeqiNP_856583.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96625; CAD96625; Mb2938c.
GeneIDi1092167.
KEGGimbo:Mb2938c.
PATRICi18008184. VBIMycBov88188_3224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44205.1 .
RefSeqi NP_856583.1. NC_002945.3.

3D structure databases

ProteinModelPortali P65731.
SMRi P65731. Positions 12-246.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233413.Mb2938c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96625 ; CAD96625 ; Mb2938c .
GeneIDi 1092167.
KEGGi mbo:Mb2938c.
PATRICi 18008184. VBIMycBov88188_3224.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000047111.
KOi K08884.
OMAi NILLTHP.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNI_MYCBO
AccessioniPrimary (citable) accession number: P65731
Secondary accession number(s): Q10964, X2BMF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi