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P65731

- PKNI_MYCBO

UniProt

P65731 - PKNI_MYCBO

Protein

Serine/threonine-protein kinase PknI

Gene

pknI

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Plays an important role in slowing down the growth of mycobacteria within the infected host.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATPPROSITE-ProRule annotation
    Active sitei137 – 1371Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknI (EC:2.7.11.1)
    Gene namesi
    Name:pknI
    Ordered Locus Names:Mb2938c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Serine/threonine-protein kinase PknIPRO_0000171219Add
    BLAST

    Post-translational modificationi

    Autophosphorylated at serine and threonine residues.By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2938c.

    Structurei

    3D structure databases

    ProteinModelPortaliP65731.
    SMRiP65731. Positions 12-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 349349CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini371 – 585215ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 252241Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000047111.
    KOiK08884.
    OMAiNILLTHP.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALASGVTFA GYTVVRMLGC SAMGEVYLVQ HPGFPGWQAL KVLSPAMAAD    50
    DEFRRRFQRE TEVAARLFHP HILEVHDRGE FDGQLWIAMD YVDGIDATQH 100
    MADRFPAVLP VGEVLAIVTA VAGALDYAHQ RGLLHRDVNP ANVVLTSQSA 150
    GDQRILLADF GIASQPSYPA PELSAGADVD GRADQYALAL TAIHLFAGAP 200
    PVDRSHTGPL QPPKLSAFRP DLARLDGVLS RALATAPADR FGSCREFADA 250
    MNEQAGVAIA DQSSGGVDAS EVTAAAGEEA YVVDYPAYGW PEAVDCKEPS 300
    ARAPAPAAPT PQRRGSMLQS AAGVLARRLD NFSTATKAPA SPTRRRPRRI 350
    LVGAVAVLLL AGLFAVGIVI GRKTNTTATE VARPPTSGSA VPSAPTTTVA 400
    VTAPVPLDGT YRIEIQRSKQ TYDYTPTPQP PDVNTWWAFR TSCTPTECLA 450
    AATMLDDNDH TQAKTPPVRP FLMQFGEGQW KSRPETVQFP CVGPNGSPST 500
    QATTQLLALR PQPQGDLVGE MVVTVHSNEC GQQGAVIRIP AVASRSGDLP 550
    PAVTVPDPAT IPDTPDTTST ATLTPPTTTA PGPGR 585
    Length:585
    Mass (Da):61,805
    Last modified:October 11, 2004 - v1
    Checksum:iE52EACFF4A69C3EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44205.1.
    RefSeqiNP_856583.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96625; CAD96625; Mb2938c.
    GeneIDi1092167.
    KEGGimbo:Mb2938c.
    PATRICi18008184. VBIMycBov88188_3224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44205.1 .
    RefSeqi NP_856583.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P65731.
    SMRi P65731. Positions 12-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2938c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96625 ; CAD96625 ; Mb2938c .
    GeneIDi 1092167.
    KEGGi mbo:Mb2938c.
    PATRICi 18008184. VBIMycBov88188_3224.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000047111.
    KOi K08884.
    OMAi NILLTHP.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPKNI_MYCBO
    AccessioniPrimary (citable) accession number: P65731
    Secondary accession number(s): Q10964, X2BMF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3