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P65729

- PKNG_MYCBO

UniProt

P65729 - PKNG_MYCBO

Protein

Serine/threonine-protein kinase PknG

Gene

pknG

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei181 – 1811ATPPROSITE-ProRule annotation
    Active sitei276 – 2761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi157 – 1659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknG (EC:2.7.11.1)
    Gene namesi
    Name:pknG
    Ordered Locus Names:Mb0418c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 750750Serine/threonine-protein kinase PknGPRO_0000171214Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb0418c.

    Structurei

    3D structure databases

    ProteinModelPortaliP65729.
    SMRiP65729. Positions 74-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini151 – 396246Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049016.
    KOiK14949.
    OMAiHRYALVD.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65729-1 [UniParc]FASTAAdd to Basket

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    MAKASETERS GPGTQPADAQ TATSATVRPL STQAVFRPDF GDEDNFPHPT    50
    LGPDTEPQDR MATTSRVRPP VRRLGGGLVE IPRAPDIDPL EALMTNPVVP 100
    ESKRFCWNCG RPVGRSDSET KGASEGWCPY CGSPYSFLPQ LNPGDIVAGQ 150
    YEVKGCIAHG GLGWIYLALD RNVNGRPVVL KGLVHSGDAE AQAMAMAERQ 200
    FLAEVVHPSI VQIFNFVEHT DRHGDPVGYI VMEYVGGQSL KRSKGQKLPV 250
    AEAIAYLLEI LPALSYLHSI GLVYNDLKPE NIMLTEEQLK LIDLGAVSRI 300
    NSFGYLYGTP GFQAPEIVRT GPTVATDIYT VGRTLAALTL DLPTRNGRYV 350
    DGLPEDDPVL KTYDSYGRLL RRAIDPDPRQ RFTTAEEMSA QLTGVLREVV 400
    AQDTGVPRPG LSTIFSPSRS TFGVDLLVAH TDVYLDGQVH AEKLTANEIV 450
    TALSVPLVDP TDVAASVLQA TVLSQPVQTL DSLRAARHGA LDADGVDFSE 500
    SVELPLMEVR ALLDLGDVAK ATRKLDDLAE RVGWRWRLVW YRAVAELLTG 550
    DYDSATKHFT EVLDTFPGEL APKLALAATA ELAGNTDEHK FYQTVWSTND 600
    GVISAAFGLA RARSAEGDRV GAVRTLDEVP PTSRHFTTAR LTSAVTLLSG 650
    RSTSEVTEEQ IRDAARRVEA LPPTEPRVLQ IRALVLGGAL DWLKDNKAST 700
    NHILGFPFTS HGLRLGVEAS LRSLARVAPT QRHRYTLVDM ANKVRPTSTF 750
    Length:750
    Mass (Da):81,577
    Last modified:October 11, 2004 - v1
    Checksum:iCFC6E54DBE19569F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41657.1.
    RefSeqiNP_854081.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD93281; CAD93281; Mb0418c.
    GeneIDi1091420.
    KEGGimbo:Mb0418c.
    PATRICi18002575. VBIMycBov88188_0456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41657.1 .
    RefSeqi NP_854081.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P65729.
    SMRi P65729. Positions 74-746.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb0418c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD93281 ; CAD93281 ; Mb0418c .
    GeneIDi 1091420.
    KEGGi mbo:Mb0418c.
    PATRICi 18002575. VBIMycBov88188_0456.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049016.
    KOi K14949.
    OMAi HRYALVD.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPKNG_MYCBO
    AccessioniPrimary (citable) accession number: P65729
    Secondary accession number(s): P96256, X2BEZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3