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P65729

- PKNG_MYCBO

UniProt

P65729 - PKNG_MYCBO

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Protein

Serine/threonine-protein kinase PknG

Gene

pknG

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811ATPPROSITE-ProRule annotation
Active sitei276 – 2761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1659ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknG (EC:2.7.11.1)
Gene namesi
Name:pknG
Ordered Locus Names:Mb0418c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Serine/threonine-protein kinase PknGPRO_0000171214Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb0418c.

Structurei

3D structure databases

ProteinModelPortaliP65729.
SMRiP65729. Positions 74-746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 396246Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000049016.
KOiK14949.
OMAiHRYALVD.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65729-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKASETERS GPGTQPADAQ TATSATVRPL STQAVFRPDF GDEDNFPHPT
60 70 80 90 100
LGPDTEPQDR MATTSRVRPP VRRLGGGLVE IPRAPDIDPL EALMTNPVVP
110 120 130 140 150
ESKRFCWNCG RPVGRSDSET KGASEGWCPY CGSPYSFLPQ LNPGDIVAGQ
160 170 180 190 200
YEVKGCIAHG GLGWIYLALD RNVNGRPVVL KGLVHSGDAE AQAMAMAERQ
210 220 230 240 250
FLAEVVHPSI VQIFNFVEHT DRHGDPVGYI VMEYVGGQSL KRSKGQKLPV
260 270 280 290 300
AEAIAYLLEI LPALSYLHSI GLVYNDLKPE NIMLTEEQLK LIDLGAVSRI
310 320 330 340 350
NSFGYLYGTP GFQAPEIVRT GPTVATDIYT VGRTLAALTL DLPTRNGRYV
360 370 380 390 400
DGLPEDDPVL KTYDSYGRLL RRAIDPDPRQ RFTTAEEMSA QLTGVLREVV
410 420 430 440 450
AQDTGVPRPG LSTIFSPSRS TFGVDLLVAH TDVYLDGQVH AEKLTANEIV
460 470 480 490 500
TALSVPLVDP TDVAASVLQA TVLSQPVQTL DSLRAARHGA LDADGVDFSE
510 520 530 540 550
SVELPLMEVR ALLDLGDVAK ATRKLDDLAE RVGWRWRLVW YRAVAELLTG
560 570 580 590 600
DYDSATKHFT EVLDTFPGEL APKLALAATA ELAGNTDEHK FYQTVWSTND
610 620 630 640 650
GVISAAFGLA RARSAEGDRV GAVRTLDEVP PTSRHFTTAR LTSAVTLLSG
660 670 680 690 700
RSTSEVTEEQ IRDAARRVEA LPPTEPRVLQ IRALVLGGAL DWLKDNKAST
710 720 730 740 750
NHILGFPFTS HGLRLGVEAS LRSLARVAPT QRHRYTLVDM ANKVRPTSTF
Length:750
Mass (Da):81,577
Last modified:October 11, 2004 - v1
Checksum:iCFC6E54DBE19569F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41657.1.
RefSeqiNP_854081.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD93281; CAD93281; Mb0418c.
GeneIDi1091420.
KEGGimbo:Mb0418c.
PATRICi18002575. VBIMycBov88188_0456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41657.1 .
RefSeqi NP_854081.1. NC_002945.3.

3D structure databases

ProteinModelPortali P65729.
SMRi P65729. Positions 74-746.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb0418c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD93281 ; CAD93281 ; Mb0418c .
GeneIDi 1091420.
KEGGi mbo:Mb0418c.
PATRICi 18002575. VBIMycBov88188_0456.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000049016.
KOi K14949.
OMAi HRYALVD.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPKNG_MYCBO
AccessioniPrimary (citable) accession number: P65729
Secondary accession number(s): P96256, X2BEZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3