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P65727 (PKNA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknA

EC=2.7.11.1
Gene names
Name:pknA
Ordered Locus Names:Mb0015c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Serine/threonine-protein kinase PknA
PRO_0000171203

Regions

Topological domain1 – 339339Cytoplasmic Potential
Transmembrane340 – 36021Helical; Potential
Topological domain361 – 43171Extracellular Potential
Domain13 – 272260Protein kinase
Nucleotide binding19 – 279ATP By similarity

Sites

Active site1411Proton acceptor By similarity
Binding site421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P65727 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 582D183747F3C111

FASTA43145,597
        10         20         30         40         50         60 
MSPRVGVTLS GRYRLQRLIA TGGMGQVWEA VDNRLGRRVA VKVLKSEFSS DPEFIERFRA 

        70         80         90        100        110        120 
EARTTAMLNH PGIASVHDYG ESQMNGEGRT AYLVMELVNG EPLNSVLKRT GRLSLRHALD 

       130        140        150        160        170        180 
MLEQTGRALQ IAHAAGLVHR DVKPGNILIT PTGQVKITDF GIAKAVDAAP VTQTGMVMGT 

       190        200        210        220        230        240 
AQYIAPEQAL GHDASPASDV YSLGVVGYEA VSGKRPFAGD GALTVAMKHI KEPPPPLPPD 

       250        260        270        280        290        300 
LPPNVRELIE ITLVKNPAMR YRSGGPFADA VAAVRAGRRP PRPSQTPPPG RAAPAAIPSG 

       310        320        330        340        350        360 
TTARVAANSA GRTAASRRSR PATGGHRPPR RTFSSGQRAL LWAAGVLGAL AIIIAVLLVI 

       370        380        390        400        410        420 
KAPGDNSPQQ APTPTVTTTG NPPASNTGGT DASPRLNWTE RGETRHSGLQ SWVVPPTPHS 

       430 
RASLARYEIA Q 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248334 Genomic DNA. Translation: CAD92877.1.
RefSeqNP_853685.1. NC_002945.3.

3D structure databases

ProteinModelPortalP65727.
SMRP65727. Positions 9-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb0015c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD92877; CAD92877; Mb0015c.
GeneID1090760.
KEGGmbo:Mb0015c.
PATRIC18001699. VBIMycBov88188_0019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000037187.
KOK08884.
OMAFVERFRI.
OrthoDBEOG6C01CH.
ProtClustDBCLSK790193.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNA_MYCBO
AccessionPrimary (citable) accession number: P65727
Secondary accession number(s): P71585
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families