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P65717

- PTPA_MYCBO

UniProt

P65717 - PTPA_MYCBO

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Protein

Probable low molecular weight protein-tyrosine-phosphatase

Gene
ptpA, Mb2258
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Nucleophile By similarity
Active sitei17 – 171 By similarity
Active sitei126 – 1261Proton donor By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Short name:
PTPase
Gene namesi
Name:ptpA
Ordered Locus Names:Mb2258
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Probable low molecular weight protein-tyrosine-phosphatasePRO_0000046568Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb2258.

Structurei

3D structure databases

ProteinModelPortaliP65717.
SMRiP65717. Positions 4-159.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
KOiK01104.
OMAiHTARQVT.
OrthoDBiEOG6MH5JB.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P65717-1 [UniParc]FASTAAdd to Basket

« Hide

MSDPLHVTFV CTGNICRSPM AEKMFAQQLR HRGLGDAVRV TSAGTGNWHV    50
GSCADERAAG VLRAHGYPTD HRAAQVGTEH LAADLLVALD RNHARLLRQL 100
GVEAARVRML RSFDPRSGTH ALDVEDPYYG DHSDFEEVFA VIESALPGLH 150
DWVDERLARN GPS 163
Length:163
Mass (Da):17,892
Last modified:October 11, 2004 - v1
Checksum:i9D1CF0DB24CA8E27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43514.1.
RefSeqiNP_855907.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97111; CAD97111; Mb2258.
GeneIDi1091394.
KEGGimbo:Mb2258.
PATRICi18006664. VBIMycBov88188_2478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43514.1 .
RefSeqi NP_855907.1. NC_002945.3.

3D structure databases

ProteinModelPortali P65717.
SMRi P65717. Positions 4-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2258.

Chemistry

BindingDBi P65717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97111 ; CAD97111 ; Mb2258 .
GeneIDi 1091394.
KEGGi mbo:Mb2258.
PATRICi 18006664. VBIMycBov88188_2478.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273094.
KOi K01104.
OMAi HTARQVT.
OrthoDBi EOG6MH5JB.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPTPA_MYCBO
AccessioniPrimary (citable) accession number: P65717
Secondary accession number(s): Q10507, X2BK81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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