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Protein

Probable low molecular weight protein-tyrosine-phosphatase

Gene

ptpA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileBy similarity1
Active sitei17By similarity1
Active sitei126Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Short name:
PTPase
Gene namesi
Name:ptpA
Ordered Locus Names:BQ2027_MB2258
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465681 – 163Probable low molecular weight protein-tyrosine-phosphataseAdd BLAST163

Structurei

3D structure databases

ProteinModelPortaliP65717.
SMRiP65717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000273094.
KOiK01104.
OMAiAGTGSWH.

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase.
IPR036196. Ptyr_pPase_sf.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P65717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPLHVTFV CTGNICRSPM AEKMFAQQLR HRGLGDAVRV TSAGTGNWHV
60 70 80 90 100
GSCADERAAG VLRAHGYPTD HRAAQVGTEH LAADLLVALD RNHARLLRQL
110 120 130 140 150
GVEAARVRML RSFDPRSGTH ALDVEDPYYG DHSDFEEVFA VIESALPGLH
160
DWVDERLARN GPS
Length:163
Mass (Da):17,892
Last modified:October 11, 2004 - v1
Checksum:i9D1CF0DB24CA8E27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU00868.1.
RefSeqiNP_855907.1. NC_002945.3.
WP_003411510.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO43514; CDO43514; Mb2258.
KEGGimbo:Mb2258.
PATRICifig|233413.5.peg.2478.

Similar proteinsi

Entry informationi

Entry nameiPTPA_MYCBO
AccessioniPrimary (citable) accession number: P65717
Secondary accession number(s): A0A1R3Y0K0, Q10507, X2BK81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families