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P65717 (PTPA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable low molecular weight protein-tyrosine-phosphatase

Short name=PTPase
EC=3.1.3.48
Gene names
Name:ptpA
Ordered Locus Names:Mb2258
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Probable low molecular weight protein-tyrosine-phosphatase
PRO_0000046568

Sites

Active site111Nucleophile By similarity
Active site171 By similarity
Active site1261Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P65717 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9D1CF0DB24CA8E27

FASTA16317,892
        10         20         30         40         50         60 
MSDPLHVTFV CTGNICRSPM AEKMFAQQLR HRGLGDAVRV TSAGTGNWHV GSCADERAAG 

        70         80         90        100        110        120 
VLRAHGYPTD HRAAQVGTEH LAADLLVALD RNHARLLRQL GVEAARVRML RSFDPRSGTH 

       130        140        150        160 
ALDVEDPYYG DHSDFEEVFA VIESALPGLH DWVDERLARN GPS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO43514.1.
RefSeqNP_855907.1. NC_002945.3.

3D structure databases

ProteinModelPortalP65717.
SMRP65717. Positions 4-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2258.

Chemistry

BindingDBP65717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD97111; CAD97111; Mb2258.
GeneID1091394.
KEGGmbo:Mb2258.
PATRIC18006664. VBIMycBov88188_2478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273094.
KOK01104.
OMAHTARQVT.
OrthoDBEOG6MH5JB.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTPA_MYCBO
AccessionPrimary (citable) accession number: P65717
Secondary accession number(s): Q10507, X2BK81
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families