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Protein

Probable low molecular weight protein-tyrosine-phosphatase

Gene

ptpA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileBy similarity
Active sitei17 – 171By similarity
Active sitei126 – 1261Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Short name:
PTPase
Gene namesi
Name:ptpA
Ordered Locus Names:Mb2258
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Probable low molecular weight protein-tyrosine-phosphatasePRO_0000046568Add
BLAST

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP65717.
SMRiP65717. Positions 4-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
KOiK01104.
OMAiGSWHIGK.
OrthoDBiEOG6MH5JB.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P65717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPLHVTFV CTGNICRSPM AEKMFAQQLR HRGLGDAVRV TSAGTGNWHV
60 70 80 90 100
GSCADERAAG VLRAHGYPTD HRAAQVGTEH LAADLLVALD RNHARLLRQL
110 120 130 140 150
GVEAARVRML RSFDPRSGTH ALDVEDPYYG DHSDFEEVFA VIESALPGLH
160
DWVDERLARN GPS
Length:163
Mass (Da):17,892
Last modified:October 11, 2004 - v1
Checksum:i9D1CF0DB24CA8E27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43514.1.
RefSeqiNP_855907.1. NC_002945.3.
WP_003411510.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43514; CDO43514; Mb2258.
GeneIDi1091394.
KEGGimbo:Mb2258.
PATRICi18006664. VBIMycBov88188_2478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43514.1.
RefSeqiNP_855907.1. NC_002945.3.
WP_003411510.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP65717.
SMRiP65717. Positions 4-159.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP65717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43514; CDO43514; Mb2258.
GeneIDi1091394.
KEGGimbo:Mb2258.
PATRICi18006664. VBIMycBov88188_2478.

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
KOiK01104.
OMAiGSWHIGK.
OrthoDBiEOG6MH5JB.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPTPA_MYCBO
AccessioniPrimary (citable) accession number: P65717
Secondary accession number(s): Q10507, X2BK81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.