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P65717

- PTPA_MYCBO

UniProt

P65717 - PTPA_MYCBO

Protein

Probable low molecular weight protein-tyrosine-phosphatase

Gene

ptpA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111NucleophileBy similarity
    Active sitei17 – 171By similarity
    Active sitei126 – 1261Proton donorBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
    Short name:
    PTPase
    Gene namesi
    Name:ptpA
    Ordered Locus Names:Mb2258
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Probable low molecular weight protein-tyrosine-phosphatasePRO_0000046568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2258.

    Structurei

    3D structure databases

    ProteinModelPortaliP65717.
    SMRiP65717. Positions 4-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273094.
    KOiK01104.
    OMAiHTARQVT.
    OrthoDBiEOG6MH5JB.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P65717-1 [UniParc]FASTAAdd to Basket

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    MSDPLHVTFV CTGNICRSPM AEKMFAQQLR HRGLGDAVRV TSAGTGNWHV    50
    GSCADERAAG VLRAHGYPTD HRAAQVGTEH LAADLLVALD RNHARLLRQL 100
    GVEAARVRML RSFDPRSGTH ALDVEDPYYG DHSDFEEVFA VIESALPGLH 150
    DWVDERLARN GPS 163
    Length:163
    Mass (Da):17,892
    Last modified:October 11, 2004 - v1
    Checksum:i9D1CF0DB24CA8E27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43514.1.
    RefSeqiNP_855907.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD97111; CAD97111; Mb2258.
    GeneIDi1091394.
    KEGGimbo:Mb2258.
    PATRICi18006664. VBIMycBov88188_2478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43514.1 .
    RefSeqi NP_855907.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P65717.
    SMRi P65717. Positions 4-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2258.

    Chemistry

    BindingDBi P65717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD97111 ; CAD97111 ; Mb2258 .
    GeneIDi 1091394.
    KEGGi mbo:Mb2258.
    PATRICi 18006664. VBIMycBov88188_2478.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273094.
    KOi K01104.
    OMAi HTARQVT.
    OrthoDBi EOG6MH5JB.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPTPA_MYCBO
    AccessioniPrimary (citable) accession number: P65717
    Secondary accession number(s): Q10507, X2BK81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3