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Reviewed, UniProtKB/Swiss-Prot P65681 (PDXA_BRUSU)

Last modified June 16, 2009. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-hydroxythreonine-4-phosphate dehydrogenase
    EC=1.1.1.262
Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name: pdxA
Ordered Locus Names: BR0683
OrganismBrucella suis [Complete proteome] [HAMAP]
Taxonomic identifier29461 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.

Catalytic activity

4-(phosphonooxy)-L-threonine + NAD+ = (2S)-2-amino-3-oxo-4-phosphonooxybutanoate + NADH. HAMAP MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP MF_00536

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the pdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3433434-hydroxythreonine-4-phosphate dehydrogenase HAMAP MF_00536
PRO_0000188801

Sites

Metal binding1761Divalent metal cation; shared with dimeric partner By similarity
Metal binding2211Divalent metal cation; shared with dimeric partner By similarity
Metal binding2761Divalent metal cation; shared with dimeric partner By similarity
Binding site1411Substrate By similarity
Binding site1421Substrate By similarity
Binding site2841Substrate By similarity
Binding site2931Substrate By similarity
Binding site3021Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P65681-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: FBF6CA0AB6D28617

FASTA34336,193
        10         20         30         40         50         60 
MRAKPLPPLA VSIGDPSGIG ADVALAAWLK RCELSLPPFF LIADPKQLAA RARHLGLAVD 

        70         80         90        100        110        120 
FAILSDPREA EAAFGERLPL LALKHSHTES PGKPLTENAA GVIEAIERAV ELTLKGEAAA 

       130        140        150        160        170        180 
VVTCPIAKKP LYEAGFQHPG HTEFLAELAG HHLGKPVTPV MMLAGPQLRA VPVTIHIPLS 

       190        200        210        220        230        240 
EVPARLTTTE IVAVSRITAN ELRERFGIAS PRLAISGLNP HAGEGGALGK EDDAIILPAI 

       250        260        270        280        290        300 
EQLIREGIDA RGPLPADTMF HAPARATYDA AICMYHDQAL IPAKALAFDE TVNVTLGLPF 

       310        320        330        340 
IRTSPDHGTA FDIAGKGIAR PDSLVAAMRL AQQLAENAAS RNA 

« Hide

Cross-references

Sequence databases

AE014291 Genomic DNA. Translation: AAN29612.1.
RefSeqNP_697697.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1166346.
GenomeReviewsGene locus BR0683 in contig AE014291_GR.
KEGGbms:BR0683.
TIGRBR0683.

Phylogenomic databases

HOGENOMP65681.
OMAP65681. QPKYLQD.

Enzyme and pathway databases

BioCycBSUI204722:BR_0683-MON.
BRENDA1.1.1.262. 281610.

Family and domain databases

HAMAPMF_00536.
[Tree]
InterProIPR005255. PyrdxlP_synth_PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_BRUSU
AccessionPrimary (citable) accession number: P65681
Secondary accession number(s): P58712
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella suis

Brucella suis (strain 1330): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents