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P65677

- PCP_STAAN

UniProt

P65677 - PCP_STAAN

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, SA2482
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity
Active sitei141 – 1411 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:SA2482
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Pyrrolidone-carboxylate peptidaseUniRule annotation
PRO_0000184733Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi158879.SA2482.

Structurei

3D structure databases

ProteinModelPortaliP65677.
SMRiP65677. Positions 1-212.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65677-1 [UniParc]FASTAAdd to Basket

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MHILVTGFAP FDNQNINPSW EAVTQLEDII GTHTIDKLKL PTSFKKVDNI    50
INKTLASNHY DVVLAIGQAG GRNAITPERV AINIDDARIP DNDDFQPIDQ 100
AIHLDGAPAY FSNLPVKAMT QSIINQGLPG ALSNSAGTYV CNHVLYHLGY 150
LQDKHYPHLR FGFIHVPYIP EQVIGKPDTP SMPLEKIVAG LTAAIEAISN 200
DEDLRIALGT TE 212
Length:212
Mass (Da):23,200
Last modified:October 11, 2004 - v1
Checksum:i6155D77BE79B68DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43788.1.
PIRiB90078.
RefSeqiNP_375809.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43788; BAB43788; BAB43788.
GeneIDi1125412.
KEGGisau:SA2482.
PATRICi19577536. VBIStaAur116463_2686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43788.1 .
PIRi B90078.
RefSeqi NP_375809.1. NC_002745.2.

3D structure databases

ProteinModelPortali P65677.
SMRi P65677. Positions 1-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA2482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB43788 ; BAB43788 ; BAB43788 .
GeneIDi 1125412.
KEGGi sau:SA2482.
PATRICi 19577536. VBIStaAur116463_2686.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-2646-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiPCP_STAAN
AccessioniPrimary (citable) accession number: P65677
Secondary accession number(s): Q99QV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi