Reviewed, UniProtKB/Swiss-Prot P65671 (CYSD_MYCBO)

Names and origin

Protein names

Recommended name:
    Sulfate adenylyltransferase subunit 2
    EC=2.7.7.4
Alternative name(s):
    Sulfate adenylate transferase
      Short name=SAT
    ATP-sulfurylase small subunit

Gene names

Name:	cysD
Ordered Locus Names:	Mb1316

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + sulfate = diphosphate + adenylyl sulfate. HAMAP MF_00064
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. HAMAP MF_00064
Subunit structure	Heterodimer composed of cysD, the smaller subunit, and cysN By similarity.
Sequence similarities	Belongs to the PAPS reductase family. CysD subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP sulfate reduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW sulfate adenylyltransferase (ATP) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Sulfate adenylyltransferase subunit 2 HAMAP MF_00064		PRO_0000100668

Sequences

	Sequence		Length	Mass (Da)
	P65671-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 75D965D35F1EC284	FASTA	309	34,889
	10 20 30 40 50 60 MTSDVTVGPA PGQYQLSHLR LLEAEAIHVI REVAAEFERP VLLFSGGKDS IVMLHLALKA 70 80 90 100 110 120 FRPGRLPFPV MHVDTGHNFD EVIATRDELV AAAGVRLVVA SVQDDIDAGR VVETIPSRNP 130 140 150 160 170 180 IQTVTLLRAI RENQFDAAFG GARRDEEKAR AKERVFSFRD EFGQWDPKAQ RPELWNLYNG 190 200 210 220 230 240 RHHKGEHIRV FPLSNWTEFD IWSYIGAEQV RLPSIYFAHR RKVFQRDGML LAVHRHMQPR 250 260 270 280 290 300 ADEPVFEATV RFRTVGDVTC TGCVESSAST VAEVIAETAV ARLTERGATR ADDRISEAGM EDRKRQGYF

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248338 Genomic DNA. Translation: CAD94177.1. Different initiation.
RefSeq	NP_854970.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1090603.
GenomeReviews	Gene locus Mb1316 in contig BX248333_GR.
KEGG	mbo:Mb1316.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P65671.
Enzyme and pathway databases
BRENDA	2.7.7.4. 3091.
Family and domain databases
HAMAP	MF_00064. [Tree]
InterPro	IPR002500. PAPS_reduct. IPR014729. Rossmann-like_a/b/a_fold. IPR011784. SO4_adenylTrfase_ssu. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
PIRSF	PIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMs	TIGR02039. CysD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSD_MYCBO

Accession

Primary (citable) accession number: P65671
Secondary accession number(s): Q10599

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)