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P65666

- PANE_STRP1

UniProt

P65666 - PANE_STRP1

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Protein

Putative 2-dehydropantoate 2-reductase

Gene
apbA, SPy_0852, M5005_Spy0659
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADP; via amide nitrogen By similarity
Binding sitei102 – 1021Substrate By similarity
Active sitei184 – 1841Proton donor By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei255 – 2551Substrate By similarity
Binding sitei268 – 2681NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-700-MONOMER.
SPYO293653:GHFC-715-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:apbA
Ordered Locus Names:SPy_0852, M5005_Spy0659
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Putative 2-dehydropantoate 2-reductasePRO_0000157318Add
BLAST

Proteomic databases

PaxDbiP65666.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0852.

Structurei

3D structure databases

ProteinModelPortaliP65666.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiMGLEPML.
OrthoDBiEOG6P5ZHG.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

P65666-1 [UniParc]FASTAAdd to Basket

« Hide

MLVYIAGSGA MGCRFGYQIS KTNNDVILLD NWEDHINAIK ENGLVVTGDV    50
EETVKLPIMK PTEATQEADL IILFTKAMQL PQMLQDIKGI IGKETKVLCL 100
LNGLGHEDVI RQYIPEHNIL MGVTVWTAGL EGPGRAHLQG VGALNLQSMD 150
PSNQEAGHQV ADLLNEANLN ATYDENVVPN IWRKACVNGT MNSTCALLDC 200
TIGELFASED GLKMVKEIIH EFVIVGQAEG VELNEEEITQ YVMDTSVKAA 250
HHYPSMHQDL VQNHRLTEID FINGAVNTKG EKLGINTPYC RMITELVHAK 300
EAVLNIQ 307
Length:307
Mass (Da):33,829
Last modified:October 11, 2004 - v1
Checksum:i46F6298D3BD958E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33780.1.
CP000017 Genomic DNA. Translation: AAZ51277.1.
RefSeqiNP_269059.1. NC_002737.1.
YP_282022.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33780; AAK33780; SPy_0852.
AAZ51277; AAZ51277; M5005_Spy0659.
GeneIDi3572249.
901016.
KEGGispy:SPy_0852.
spz:M5005_Spy_0659.
PATRICi19715322. VBIStrPyo79812_0729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33780.1 .
CP000017 Genomic DNA. Translation: AAZ51277.1 .
RefSeqi NP_269059.1. NC_002737.1.
YP_282022.1. NC_007297.1.

3D structure databases

ProteinModelPortali P65666.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0852.

Proteomic databases

PaxDbi P65666.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33780 ; AAK33780 ; SPy_0852 .
AAZ51277 ; AAZ51277 ; M5005_Spy0659 .
GeneIDi 3572249.
901016.
KEGGi spy:SPy_0852.
spz:M5005_Spy_0659.
PATRICi 19715322. VBIStrPyo79812_0729.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi MGLEPML.
OrthoDBi EOG6P5ZHG.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci SPYO160490:GJ81-700-MONOMER.
SPYO293653:GHFC-715-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiPANE_STRP1
AccessioniPrimary (citable) accession number: P65666
Secondary accession number(s): Q48ZE1, Q9A0B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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