Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P65666

- PANE_STRP1

UniProt

P65666 - PANE_STRP1

Protein

Putative 2-dehydropantoate 2-reductase

Gene

apbA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADP; via amide nitrogenBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei184 – 1841Proton donorBy similarity
    Binding sitei188 – 1881SubstrateBy similarity
    Binding sitei192 – 1921SubstrateBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Binding sitei268 – 2681NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-700-MONOMER.
    SPYO293653:GHFC-715-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:apbA
    Ordered Locus Names:SPy_0852, M5005_Spy0659
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Putative 2-dehydropantoate 2-reductasePRO_0000157318Add
    BLAST

    Proteomic databases

    PaxDbiP65666.

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_0852.

    Structurei

    3D structure databases

    ProteinModelPortaliP65666.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiMGLEPML.
    OrthoDBiEOG6P5ZHG.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P65666-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVYIAGSGA MGCRFGYQIS KTNNDVILLD NWEDHINAIK ENGLVVTGDV    50
    EETVKLPIMK PTEATQEADL IILFTKAMQL PQMLQDIKGI IGKETKVLCL 100
    LNGLGHEDVI RQYIPEHNIL MGVTVWTAGL EGPGRAHLQG VGALNLQSMD 150
    PSNQEAGHQV ADLLNEANLN ATYDENVVPN IWRKACVNGT MNSTCALLDC 200
    TIGELFASED GLKMVKEIIH EFVIVGQAEG VELNEEEITQ YVMDTSVKAA 250
    HHYPSMHQDL VQNHRLTEID FINGAVNTKG EKLGINTPYC RMITELVHAK 300
    EAVLNIQ 307
    Length:307
    Mass (Da):33,829
    Last modified:October 11, 2004 - v1
    Checksum:i46F6298D3BD958E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33780.1.
    CP000017 Genomic DNA. Translation: AAZ51277.1.
    RefSeqiNP_269059.1. NC_002737.1.
    YP_282022.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33780; AAK33780; SPy_0852.
    AAZ51277; AAZ51277; M5005_Spy0659.
    GeneIDi3572249.
    901016.
    KEGGispy:SPy_0852.
    spz:M5005_Spy_0659.
    PATRICi19715322. VBIStrPyo79812_0729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33780.1 .
    CP000017 Genomic DNA. Translation: AAZ51277.1 .
    RefSeqi NP_269059.1. NC_002737.1.
    YP_282022.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P65666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_0852.

    Proteomic databases

    PaxDbi P65666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33780 ; AAK33780 ; SPy_0852 .
    AAZ51277 ; AAZ51277 ; M5005_Spy0659 .
    GeneIDi 3572249.
    901016.
    KEGGi spy:SPy_0852.
    spz:M5005_Spy_0659.
    PATRICi 19715322. VBIStrPyo79812_0729.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi MGLEPML.
    OrthoDBi EOG6P5ZHG.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci SPYO160490:GJ81-700-MONOMER.
    SPYO293653:GHFC-715-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiPANE_STRP1
    AccessioniPrimary (citable) accession number: P65666
    Secondary accession number(s): Q48ZE1, Q9A0B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3