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Protein

1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene

menA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).UniRule annotation

Catalytic activityi

An all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMenaquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00079; UER00168.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoate octaprenyltransferaseUniRule annotation (EC:2.5.1.74UniRule annotation)
Short name:
DHNA-octaprenyltransferaseUniRule annotation
Gene namesi
Name:menAUniRule annotation
Ordered Locus Names:BQ2027_MB0548C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei166 – 186HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964161 – 2921,4-dihydroxy-2-naphthoate octaprenyltransferaseAdd BLAST292

Structurei

3D structure databases

ProteinModelPortaliP65651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MenA family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000028298.
KOiK02548.
OMAiPPMYSVA.

Family and domain databases

HAMAPiMF_01937. MenA_1. 1 hit.
InterProiView protein in InterPro
IPR004657. MenA.
IPR000537. UbiA_prenyltransferase.
IPR026046. UBIAD1.
PfamiView protein in Pfam
PF01040. UbiA. 1 hit.
PIRSFiPIRSF005355. UBIAD1. 1 hit.

Sequencei

Sequence statusi: Complete.

P65651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFAQWVSG ARPRTLPNAI APVVAGTGAA AWLHAAVWWK ALLALAVAVA
60 70 80 90 100
LVIGVNYAND YSDGIRGTDD DRVGPVRLVG SRLATPRSVL TAAMTSLALG
110 120 130 140 150
ALAGLVLALL SAPWLIAVGA ICIAGAWLYT GGSKPYGYAG FGELAVFVFF
160 170 180 190 200
GPVAVLGTQY TQALRVDWVG LAQAVATGAL SCSVLVANNL RDIPTDARAD
210 220 230 240 250
KITLAVRLGD ARTRMLYQGL LAVAGVLTFV LMLATPWCVV GLVAAPLALR
260 270 280 290
AAGPVRSGRG GRELIPVLRD TGLAMLVWAL AVAGALAFGQ LS
Length:292
Mass (Da):30,014
Last modified:October 11, 2004 - v1
Checksum:iFF73431AB309D817
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIT99144.1.
RefSeqiNP_854209.1. NC_002945.3.
WP_003402865.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO41789; CDO41789; Mb0548c.
KEGGimbo:Mb0548c.
PATRICifig|233413.5.peg.596.

Similar proteinsi

Entry informationi

Entry nameiMENA_MYCBO
AccessioniPrimary (citable) accession number: P65651
Secondary accession number(s): A0A1R3XVR1, O06400, X2BFB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families