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Protein

Ethanolamine utilization cobalamin adenosyltransferase

Gene

eutT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts CNB12 to ADOB12.By similarity

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathway:iethanolamine degradation

This protein is involved in the pathway ethanolamine degradation, which is part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the pathway ethanolamine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7289-MONOMER.
ECOL316407:JW2443-MONOMER.
UniPathwayiUPA00560.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine utilization cobalamin adenosyltransferase (EC:2.5.1.17)
Gene namesi
Name:eutT
Synonyms:ypfB
Ordered Locus Names:b2459, JW2443
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14189. eutT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Ethanolamine utilization cobalamin adenosyltransferasePRO_0000087100Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-9543N.
IntActiP65643. 7 interactions.
STRINGi511145.b2459.

Structurei

3D structure databases

ProteinModelPortaliP65643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4812.
HOGENOMiHOG000289182.
InParanoidiP65643.
KOiK04032.
OMAiACCELCH.
OrthoDBiEOG6FRCTX.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR009194. AdoCbl_synth_CblAdoTrfase_EutT.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF012294. ATR_EutT. 1 hit.
SUPFAMiSSF89028. SSF89028. 1 hit.

Sequencei

Sequence statusi: Complete.

P65643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDFITEAWL RANHTLSEGA EIHLPADSRL TPSARELLES RHLRIKFIDE
60 70 80 90 100
QGRLFVDDEQ QQPQPVHGLT SSDEHPQACC ELCRQPVAKK PDTLTHLSAE
110 120 130 140 150
KMVAKSDPRL GFRAVLDSTI ALAVWLQIEL AEPWQPWLAD IRSRLGNIMR
160 170 180 190 200
ADALGEPLGC QAIVGLSDED LHRLSHQPLR YLDHDHLVPE ASHGRDAALL
210 220 230 240 250
NLLRTKVRET ETVAAQVFIT RSFEVLRPDI LQALNRLSST VYVMMILSVT
260
KQPLTVKQIQ QRLGETQ
Length:267
Mass (Da):30,172
Last modified:October 11, 2004 - v1
Checksum:iE51EDAB528B4FA76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75512.1.
AP009048 Genomic DNA. Translation: BAE76717.1.
PIRiB65021.
RefSeqiNP_416954.1. NC_000913.3.
WP_000651298.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC75512; AAC75512; b2459.
BAE76717; BAE76717; BAE76717.
GeneIDi946939.
KEGGieco:b2459.
PATRICi32120301. VBIEscCol129921_2553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75512.1.
AP009048 Genomic DNA. Translation: BAE76717.1.
PIRiB65021.
RefSeqiNP_416954.1. NC_000913.3.
WP_000651298.1. NZ_CP010445.1.

3D structure databases

ProteinModelPortaliP65643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9543N.
IntActiP65643. 7 interactions.
STRINGi511145.b2459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75512; AAC75512; b2459.
BAE76717; BAE76717; BAE76717.
GeneIDi946939.
KEGGieco:b2459.
PATRICi32120301. VBIEscCol129921_2553.

Organism-specific databases

EchoBASEiEB3941.
EcoGeneiEG14189. eutT.

Phylogenomic databases

eggNOGiCOG4812.
HOGENOMiHOG000289182.
InParanoidiP65643.
KOiK04032.
OMAiACCELCH.
OrthoDBiEOG6FRCTX.

Enzyme and pathway databases

UniPathwayiUPA00560.
BioCyciEcoCyc:G7289-MONOMER.
ECOL316407:JW2443-MONOMER.

Miscellaneous databases

PROiP65643.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR009194. AdoCbl_synth_CblAdoTrfase_EutT.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF012294. ATR_EutT. 1 hit.
SUPFAMiSSF89028. SSF89028. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiEUTT_ECOLI
AccessioniPrimary (citable) accession number: P65643
Secondary accession number(s): P76554, Q2MAI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.