P65643 (EUTT_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ethanolamine utilization cobalamin adenosyltransferase
EC=2.5.1.17

Gene names

Name:	eutT
Synonyms:	ypfB
Ordered Locus Names:	b2459, JW2443

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts CNB12 to ADOB12 By similarity.
Catalytic activity	ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. ATP + cobinamide = triphosphate + adenosylcobinamide.
Pathway	Amine and polyamine degradation; ethanolamine degradation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: InterPro ethanolamine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cob(I)yrinic acid a,c-diamide adenosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Ethanolamine utilization cobalamin adenosyltransferase		PRO_0000087100

Sequences

	Sequence		Length	Mass (Da)
	P65643 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E51EDAB528B4FA76	FASTA	267	30,172
	10 20 30 40 50 60 MKDFITEAWL RANHTLSEGA EIHLPADSRL TPSARELLES RHLRIKFIDE QGRLFVDDEQ 70 80 90 100 110 120 QQPQPVHGLT SSDEHPQACC ELCRQPVAKK PDTLTHLSAE KMVAKSDPRL GFRAVLDSTI 130 140 150 160 170 180 ALAVWLQIEL AEPWQPWLAD IRSRLGNIMR ADALGEPLGC QAIVGLSDED LHRLSHQPLR 190 200 210 220 230 240 YLDHDHLVPE ASHGRDAALL NLLRTKVRET ETVAAQVFIT RSFEVLRPDI LQALNRLSST 250 260 VYVMMILSVT KQPLTVKQIQ QRLGETQ

References

[1]

"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.

[2]

"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75512.1. AP009048 Genomic DNA. Translation: BAE76717.1.
PIR	B65021.
RefSeq	NP_416954.1. NC_000913.2. YP_490686.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P65643.
ModBase	Search...
Protein-protein interaction databases
IntAct	P65643. 7 interactions.
STRING	511145.b2459.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75512; AAC75512; b2459. BAE76717; BAE76717; BAE76717.
GeneID	12931925. 946939.
KEGG	ecj:Y75_p2411. eco:b2459.
PATRIC	32120301. VBIEscCol129921_2553.
Organism-specific databases
EchoBASE	EB3941.
EcoGene	EG14189. eutT.
Phylogenomic databases
eggNOG	COG4812.
HOGENOM	HOG000289182.
KO	K04032.
OMA	DIMQALN.
ProtClustDB	PRK15020.
Enzyme and pathway databases
BioCyc	EcoCyc:G7289-MONOMER. ECOL316407:JW2443-MONOMER.
UniPathway	UPA00560.
Gene expression databases
Genevestigator	P65643.
Family and domain databases
Gene3D	1.20.1200.10. 1 hit.
InterPro	IPR016030. AdoCbl_synth_CblAdoTrfase-like. IPR009194. AdoCbl_synth_CblAdoTrfase_EutT. [Graphical view]
Pfam	PF01923. Cob_adeno_trans. 1 hit. [Graphical view]
PIRSF	PIRSF012294. ATR_EutT. 1 hit.
SUPFAM	SSF89028. AdoCbl_synth_CblAdoTrfase-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EUTT_ECOLI

Accession

Primary (citable) accession number: P65643
Secondary accession number(s): P76554, Q2MAI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program