P65628 (YIDC_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	SAV2090

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01811.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Chaperone
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 290	271	Membrane protein insertase YidC		PRO_0000020392
Regions
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Transmembrane	207 – 224	18	Helical; Potential
	Transmembrane	229 – 251	23	Helical; Potential
Amino acid modifications
	Lipidation	20	1	N-palmitoyl cysteine Potential
	Lipidation	20	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P65628 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 93406BE98D8F626C	FASTA	290	33,581
	10 20 30 40 50 60 MKKKALLPLF LGIMVFLAGC DYSKPEKRSG FFYNTFVDPM KNVLDWLGNN LLNDNYGLAI 70 80 90 100 110 120 IILVLVIRII LLPFMLSNYK NSHMMRQKMK VAKPEVEKIQ EKVKRARTQE EKMAANQELM 130 140 150 160 170 180 QVYKKYDMNP IKSMLGCLPM LIQLPIIMGL YFVLKDQLVD GLFKYPHFLW FDLGRPDIWI 190 200 210 220 230 240 TIIAGVLYFI QAYVSSKTMP DEQRQMGYMM MVISPIMIIW ISLSSASALG LYWSVSAAFL 250 260 270 280 290 VVQTHFANIY YEKVAKKEVQ PFIEAYEREH NGGSNKKGKN TQVVSKKKKK

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB58252.1.
RefSeq	NP_372614.1. NC_002758.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P65628.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000008186; EBSTAP00000008004; EBSTAG00000008185.
GeneID	1122107.
GenomeReviews	Gene locus SAV2090 in contig BA000017_GR.
KEGG	sav:SAV2090.
PATRIC	19565058. VBIStaAur52173_2164.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0706.
GeneTree	EBGT00050000024570.
HOGENOM	HBG560622.
OMA	IQMPIIM.
ProtClustDB	CLSK885761.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV2090-MONOMER.
Family and domain databases
HAMAP	MF_01811. YidC_type2. [Tree]
InterPro	IPR001708. Membrane_insertion_OxaA/YidC. IPR023060. OxaA_firmicutes. [Graphical view]
KO	K03217.
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP.
TIGRFAMs	TIGR03592. YidC_oxa1_C. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YIDC_STAAM

Accession

Primary (citable) accession number: P65628
Secondary accession number(s): Q99SG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program