P65616 (PYRB_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	NMB0106

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113165

Sequences

	Sequence		Length	Mass (Da)
	P65616 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: C6865145E0B7F8C9	FASTA	306	34,205
	10 20 30 40 50 60 MPNPLYRQHI ISISDLSREQ LECLLQTALK LKAHPRGDLL EGKLIGSCFF EPSTRTRLSF 70 80 90 100 110 120 ETAVQRLGGK VIGFSDGANT SAKKGETLAD TARIISGYTD AIIQRHPKDG AARVAAEFSR 130 140 150 160 170 180 VPVINAGDGT NQHPSQTLLD LVTIYETQGR LDKLKIAMAG DLKYGRTVHS LCQALKRWNC 190 200 210 220 230 240 EFAFVSPPSL AMPDYITEEL DEAGCRYRIL GSLEEAAEWA DILYMTRVQR ERFDEQEFAK 250 260 270 280 290 300 IQGKFNLEAS MLARAKPNLR VLHPLPRVDE IHPDVDATPH AYYFEQATNG VYARMAILSL VLNEEV

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF40565.1.
PIR	A81238.
RefSeq	NP_273164.1. NC_003112.2.
3D structure databases
ProteinModelPortal	P65616.
SMR	P65616. Positions 3-306.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000010665; EBNEIP00000010285; EBNEIG00000010665.
GeneID	902210.
GenomeReviews	Gene locus NMB0106 in contig AE002098_GR.
KEGG	nme:NMB0106.
PATRIC	20355225. VBINeiMen85645_0146.
TIGR	NMB0106.
Phylogenomic databases
GeneTree	EBGT00050000020730.
HOGENOM	HBG579429.
OMA	FKQSFYG.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0106-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_NEIMB

Accession

Primary (citable) accession number: P65616
Secondary accession number(s): Q9JQU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program