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Reviewed, UniProtKB/Swiss-Prot P65611 (PYRB_BRUME)

Last modified July 22, 2008. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase
Gene names
Name: pyrB
Ordered Locus Names: BMEII0670
OrganismBrucella melitensis [Complete proteome] [HAMAP]
Taxonomic identifier29459 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords

   Biological processPyrimidine biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processpyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionaspartate carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Aspartate carbamoyltransferase
PRO_0000113108

Sequences

Sequence LengthMass (Da)Tools
P65611-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 81B6208851B9521B

FASTA32234,802
        10         20         30         40         50         60 
MTNQTVSPLF PHRHLLGIKG LSPLDILCLL DLADQEIAVS RQPEKKKSVL RGRTQINLFF 

        70         80         90        100        110        120 
EASTRTQSSF ELAGKRLGAD VMNMSVGNSS VKKGETLIDT AMTLNAMQPD ILVIRHASAG 

       130        140        150        160        170        180 
AAALLAQKVG CSVVNAGDGA HEHPTQALLD ALTIRRAKGQ IENLIVAICG DVLHSRVARS 

       190        200        210        220        230        240 
NILLLNALGA RVRVVAPSTL LPAGMADMSV EVFNSMEEGL KDADVVMMLR LQRERMAGSF 

       250        260        270        280        290        300 
VPSVREYFHF YGLDREKLKF AKPDALVMHP GPMNRGVEIA SDVADGPQSV IQQQVEMGVA 

       310        320 
VRMAVMEALL DPRRNPGNGE PA 

« Hide

Cross-references

Sequence databases

AE009702 Genomic DNA. Translation: AAL53912.1.
PIRAE3593.
RefSeqNP_541648.1.

3D structure databases

HSSPHSSP built from PDB template 3CSU based on UniProtKB P00479.
ModBaseSearch...

Genome annotation databases

GeneID1198442.
GenomeReviewsGene locus BMEII0670 in contig AE008918_GR.
KEGGbme:BMEII0670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP65611.

Enzyme and pathway databases

BioCycBMEL224914:BMEII0670-MON.

Family and domain databases

HAMAPMF_00001.
[Tree]
InterProIPR006130. Asp/Orn_carbamoyltranf.
IPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082. Aspartate_carbamoyltransf_euk.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Entry information

Entry namePYRB_BRUME
AccessionPrimary (citable) accession number: P65611
Secondary accession number(s): Q8YC62
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents