P65607 (OTCC_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	SP_2150

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113035
Regions
	Region	58 – 62	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	109	1	Carbamoyl phosphate By similarity
	Binding site	136	1	Carbamoyl phosphate By similarity
	Site	33	1	Important for structural integrity By similarity
	Site	149	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P65607 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 7437F4B3502FCC1E	FASTA	338	37,911
	10 20 30 40 50 60 MTNSVFQGRS FLAEKDFTRA ELEYLIGLSA HLKDLKKRNI QHHYLAGKNI ALLFEKTSTR 70 80 90 100 110 120 TRAAFTTAAI DLGAHPEYLG ANDIQLGKKE STEDTAKVLG RMFDGIEFRG FSQRMVEELA 130 140 150 160 170 180 EFSGVPVWNG LTDEWHPTQM LADYLTVQEN FGRLEGLTLV YCGDGRNNVA NSLLVTGAIL 190 200 210 220 230 240 GVNVHIFSPK ELFPEKEIVE LAEGFAKESG AHVLITEDAD EAVKDADVLY TDVWVSMGEE 250 260 270 280 290 300 DKFAERVALL KPYQVNMDLV KKAGNENLIF LHCLPAFHDT HTVYGKDVAE KFGVEEMEVT 310 320 330 DEVFRSKYAR HFDQAENRMH TIKAVMAATL GNLYIPKV

References

[1]

"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005672 Genomic DNA. Translation: AAK76206.1.
PIR	E95251.
RefSeq	NP_346566.1. NC_003028.3.
3D structure databases
ProteinModelPortal	P65607.
SMR	P65607. Positions 5-333.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000025307; EBSTRP00000024399; EBSTRG00000025307.
GeneID	930211.
GenomeReviews	Gene locus SP_2150 in contig AE005672_GR.
KEGG	spn:SP_2150.
PATRIC	19708899. VBIStrPne105772_2241.
TIGR	SP_2150.
Phylogenomic databases
GeneTree	EBGT00050000027080.
HOGENOM	HBG579429.
OMA	VRICTPE.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	SPNE170187-1:SP_2150-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_STRPN

Accession

Primary (citable) accession number: P65607
Secondary accession number(s): Q8DN29, Q97NA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program